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Upper Reference Limits for High-Sensitivity Cardiac Troponin T and N-Terminal Fragment of the Prohormone Brain Natriuretic Peptide in Patients With CKD

Authors :
Nisha Bansal
Leila R. Zelnick
Christie M. Ballantyne
Paulo H.M. Chaves
Robert H. Christenson
Josef Coresh
Christopher R. deFilippi
James A. de Lemos
Lori B. Daniels
Alan S. Go
Jiang He
S. Susan Hedayati
Kunihiro Matsushita
Vijay Nambi
Michael G. Shlipak
Jonathan J. Taliercio
Stephen L. Seliger
Lawrence J. Appel
Harold I. Feldman
James P. Lash
Robert G. Nelson
Panduranga S. Rao
Mahboob Rahman
Vallabh O. Shah
Raymond R. Townsend
Mark L. Unruh
Source :
Am J Kidney Dis
Publication Year :
2022
Publisher :
Elsevier BV, 2022.

Abstract

RATIONALE & OBJECTIVE: The utility of conventional upper reference limits (URL) for N-terminal pro brain natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hsTnT) in chronic kidney disease (CKD) remains debated. We analyzed the distribution of hsTnT and NT-proBNP in people with CKD in ambulatory settings to examine the diagnostic value of conventional URL in this population. STUDY DESIGN: Observational study. SETTING & PARTICIPANTS: We studied participants of the Chronic Renal Insufficiency Cohort with CKD and no self-reported history of cardiovascular disease (CVD). EXPOSURE: Estimated glomerular filtration rate (eGFR). OUTCOMES: NT-proBNP and hsTnT at baseline. ANALYTICAL APPROACH:. We described the proportion of participants above the conventional URL for NT-proBNP (125 pg/ml) and hsTnT (14 ng/L) overall, and by eGFR. We then estimated 99(th) percentile URL for NT-proBNP and hsTnT. Using quantile regression of the 99(th) percentile, we modeled the association of eGFR with NT-proBNP and hsTnT. RESULTS: Among 2,312 CKD participants, 40% and 43% had levels of NT-proBNP and hsTnT above conventional URL, respectively. In those with eGFR

Details

ISSN :
02726386
Volume :
79
Database :
OpenAIRE
Journal :
American Journal of Kidney Diseases
Accession number :
edsair.doi.dedup.....cd10f341ba2317f02657e199dbbe4012
Full Text :
https://doi.org/10.1053/j.ajkd.2021.06.017