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Upper Reference Limits for High-Sensitivity Cardiac Troponin T and N-Terminal Fragment of the Prohormone Brain Natriuretic Peptide in Patients With CKD
- Source :
- Am J Kidney Dis
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- RATIONALE & OBJECTIVE: The utility of conventional upper reference limits (URL) for N-terminal pro brain natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hsTnT) in chronic kidney disease (CKD) remains debated. We analyzed the distribution of hsTnT and NT-proBNP in people with CKD in ambulatory settings to examine the diagnostic value of conventional URL in this population. STUDY DESIGN: Observational study. SETTING & PARTICIPANTS: We studied participants of the Chronic Renal Insufficiency Cohort with CKD and no self-reported history of cardiovascular disease (CVD). EXPOSURE: Estimated glomerular filtration rate (eGFR). OUTCOMES: NT-proBNP and hsTnT at baseline. ANALYTICAL APPROACH:. We described the proportion of participants above the conventional URL for NT-proBNP (125 pg/ml) and hsTnT (14 ng/L) overall, and by eGFR. We then estimated 99(th) percentile URL for NT-proBNP and hsTnT. Using quantile regression of the 99(th) percentile, we modeled the association of eGFR with NT-proBNP and hsTnT. RESULTS: Among 2,312 CKD participants, 40% and 43% had levels of NT-proBNP and hsTnT above conventional URL, respectively. In those with eGFR
- Subjects :
- medicine.medical_specialty
medicine.drug_class
Population
Renal function
Article
Troponin T
Internal medicine
Natriuretic Peptide, Brain
Natriuretic peptide
Humans
Medicine
natural sciences
cardiovascular diseases
Myocardial infarction
Renal Insufficiency, Chronic
education
education.field_of_study
biology
business.industry
medicine.disease
Brain natriuretic peptide
Troponin
Peptide Fragments
Nephrology
Heart failure
Cardiology
biology.protein
business
Biomarkers
hormones, hormone substitutes, and hormone antagonists
Glomerular Filtration Rate
Kidney disease
Subjects
Details
- ISSN :
- 02726386
- Volume :
- 79
- Database :
- OpenAIRE
- Journal :
- American Journal of Kidney Diseases
- Accession number :
- edsair.doi.dedup.....cd10f341ba2317f02657e199dbbe4012
- Full Text :
- https://doi.org/10.1053/j.ajkd.2021.06.017