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Blocking of HIV-1 infectivity by a soluble, secreted form of the CD4 antigen
- Source :
- Science (New York, N.Y.). 238(4834)
- Publication Year :
- 1987
-
Abstract
- The initial event in the infection of human T lymphocytes, macrophages, and other cells by human immunodeficiency virus (HIV-1) is the attachment of the HIV-1 envelope glycoprotein gp120 to its cellular receptor, CD4. As a step toward designing antagonists of this binding event, soluble, secreted forms of CD4 were produced by transfection of mammalian cells with vectors encoding versions of CD4 lacking its transmembrane and cytoplasmic domains. The soluble CD4 so produced binds gp120 with an affinity and specificity comparable to intact CD4 and is capable of neutralizing the infectivity of HIV-1. These studies reveal that the high-affinity CD4-gp120 interaction does not require other cell or viral components and may establish a novel basis for therapeutic intervention in the acquired immune deficiency syndrome (AIDS).
- Subjects :
- Antigens, Differentiation, T-Lymphocyte
CD4 antigen
viruses
T-Lymphocytes
Virus
Cell Line
chemistry.chemical_compound
Viral envelope
Antigen
Viral Envelope Proteins
Animals
Humans
Infectivity
Acquired Immunodeficiency Syndrome
Multidisciplinary
biology
virus diseases
HIV
Transfection
Envelope glycoprotein GP120
Virology
Recombinant Proteins
chemistry
Cell culture
biology.protein
Receptors, Virus
Subjects
Details
- ISSN :
- 00368075
- Volume :
- 238
- Issue :
- 4834
- Database :
- OpenAIRE
- Journal :
- Science (New York, N.Y.)
- Accession number :
- edsair.doi.dedup.....cd02f19c9c46f4af34b43dc8f859e0a0