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Atherosclerotic Component of the Yellow Segment After Drug-Eluting Stent Implantation on Coronary Angioscopy ― An Ex-Vivo Validation Study ―
- Source :
- Circulation Journal. 83:193-197
- Publication Year :
- 2018
- Publisher :
- Japanese Circulation Society, 2018.
-
Abstract
- BACKGROUND Coronary angioscopy (CAS) is used to comprehensively evaluate vascular responses after drug-eluting stent (DES) implantation. This study sought to evaluate the capability of CAS for evaluating DES strut coverage grade and color grade of the intima compared with histological images in coronary autopsy specimens. Methods and Results: A total of 23 DES extracted from 11 autopsy hearts were imaged by CAS. All stent segments were graded as white or yellow according to the luminal surface color, and thrombus was evaluated according to a previous report. Neointimal coverage over the DES was graded as 0 (stent struts fully visible) to grade 3 (stent struts fully embedded and invisible). Of 76 segments, neointimal coverage was graded as 0 in 35 (46%), 1 in 22 (29%), 2 in 8 (11%), and 3 in 11 (14%). The neointimal thickness increased significantly with increasing neointimal coverage grade on angioscopy. Neointimal color was graded as white in 40 (53%) and yellow in 36 segments (47%). Histological analysis revealed that yellow neointima contained fibroatheroma, foam cells accumulation or superficial calcium deposition. A thrombus was identified in 13 segments. Thrombi adherent around the stent strut were partly intimal erythrocyte accumulation around the strut. CONCLUSIONS In-stent yellow segment had atherosclerotic components. CAS could evaluate vascular status comprehensively after DES implantation.
- Subjects :
- Male
Neointima
Coronary angioscopy
medicine.medical_treatment
Angioscopy
Coronary Artery Disease
030204 cardiovascular system & hematology
medicine.disease_cause
03 medical and health sciences
0302 clinical medicine
medicine
Humans
cardiovascular diseases
030212 general & internal medicine
Thrombus
Aged
Sirolimus
medicine.diagnostic_test
business.industry
Stent
Drug-Eluting Stents
General Medicine
Middle Aged
equipment and supplies
medicine.disease
Vulnerable plaque
Plaque, Atherosclerotic
surgical procedures, operative
Drug-eluting stent
cardiovascular system
Female
Cardiology and Cardiovascular Medicine
business
Nuclear medicine
Ex vivo
Subjects
Details
- ISSN :
- 13474820 and 13469843
- Volume :
- 83
- Database :
- OpenAIRE
- Journal :
- Circulation Journal
- Accession number :
- edsair.doi.dedup.....ccf2d8a89a58c40c96a51f2cca0cc20f