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Performance evaluation of two serological tests for contagious bovine pleuropneumonia (CBPP) detection in an enzootic area using a Bayesian framework
- Source :
- Tropical Animal Health and Production
- Publication Year :
- 2012
- Publisher :
- Springer Science and Business Media LLC, 2012.
-
Abstract
- A Bayesian approach, allowing for conditional dependence between two tests was used to estimate without gold standard the sensitivities of complement fixation test (CFT) and competitive enzyme-linked immunosorbent assay test (cELISA) and the serological prevalence of CBPP in a cattle population of the Central Delta of the Niger River in Mali, where CBPP is enzootic and the true prevalence and animals serological state were unknown. A significant difference (P = 0.99) was observed between the sensitivities of the two tests, estimated at 73.7% (95% probability interval [PI], 63.4-82.7) for cELISA and 42.3% (95% PI, 33.3-53.7) for CFT. Individual-level serological prevalence in the study population was estimated at 14.1% (95% PI, 10.8-16.9). Our results indicate that in enzootic areas, cELISA performs better in terms of sensitivity than CFT. However, negative conditional sensitivity dependence between the two tests was detected, implying that to achieve maximum sensitivity, the two tests should be applied in parallel.
- Subjects :
- Veterinary medicine
Population
Cattle Diseases
Enzyme-Linked Immunosorbent Assay
Biology
Mali
L73 - Maladies des animaux
Sensitivity and Specificity
Serology
Péripneumonie contagieuse bovine
Contagious bovine pleuropneumonia
Food Animals
Seroepidemiologic Studies
medicine
Animals
Pleuropneumonia, Contagious
education
Test biologique
education.field_of_study
Conditional dependence
U10 - Informatique, mathématiques et statistiques
Technique immunologique
Complement Fixation Tests
Mycoplasma mycoides
Bayes Theorem
Gold standard (test)
medicine.disease
Complement fixation test
Population study
Enzootic
Cattle
Animal Science and Zoology
Modèle mathématique
Subjects
Details
- ISSN :
- 15737438 and 00494747
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Tropical Animal Health and Production
- Accession number :
- edsair.doi.dedup.....cccf27489b04a9663d76b3c897e2f705