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Protective Efficacy of Recombinant Modified Vaccinia Virus Ankara Delivering Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein
- Source :
- Journal of Virology
- Publication Year :
- 2015
- Publisher :
- American Society for Microbiology, 2015.
-
Abstract
- Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory disease in humans. We tested a recombinant modified vaccinia virus Ankara (MVA) vaccine expressing full-length MERS-CoV spike (S) glycoprotein by immunizing BALB/c mice with either intramuscular or subcutaneous regimens. In all cases, MVA-MERS-S induced MERS-CoV-specific CD8 + T cells and virus-neutralizing antibodies. Vaccinated mice were protected against MERS-CoV challenge infection after transduction with the human dipeptidyl peptidase 4 receptor. This MERS-CoV infection model demonstrates the safety and efficacy of the candidate vaccine.
- Subjects :
- viruses
Drug Evaluation, Preclinical
CD8-Positive T-Lymphocytes
medicine.disease_cause
law.invention
chemistry.chemical_compound
Mice
law
Viridae
Mice, Inbred BALB C
biology
Viral Vaccine
biotic associations
corona viruses
virus diseases
covid
covid-19
Spike Glycoprotein, Coronavirus
Recombinant DNA
Middle East Respiratory Syndrome Coronavirus
Antibody
Coronavirus Infections
CETAF-taskforce
Coronaviridae
Middle East respiratory syndrome coronavirus
Immunology
Vaccinia virus
Microbiology
Virus
virus-host
pathogen-host
Virology
Vaccines and Antiviral Agents
medicine
Animals
biotic relations
Dipeptidyl peptidase-4
pathogens
Viral Vaccines
biochemical phenomena, metabolism, and nutrition
biotic interaction
Antibodies, Neutralizing
respiratory tract diseases
chemistry
Insect Science
biology.protein
Vaccinia
CD8
Subjects
Details
- ISSN :
- 10985514 and 0022538X
- Volume :
- 89
- Issue :
- 16
- Database :
- OpenAIRE
- Journal :
- Journal of Virology
- Accession number :
- edsair.doi.dedup.....cccd946cff5569ad4b9804ad20b8135d
- Full Text :
- https://doi.org/10.1128/jvi.00614-15