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CT imaging features in the characterization of non-growing solid pulmonary nodules in non-smokers
- Source :
- Polish Journal of Radiology
- Publication Year :
- 2016
-
Abstract
- Summary Background A disappearing or persistent solid pulmonary nodule is a neglected clinical entity that still poses serious interpretative issues to date. Traditional knowledge deriving from previous reports suggests particular features, such as smooth edges or regular shape, to be significantly associated with benignity. A large number of benign nodules are reported among smokers in lung cancer screening programmes. The aim of this single-center retrospective study was to correlate specific imaging features to verify if traditional knowledge as well as more recent acquisitions regarding benign SPNs can be considered reliable in a current case series of nodules collected in a non-smoker cohort of patients. Material/Methods Fifty-three solid SPNs proven as non-growing during follow-up imaging were analyzed with regard to their imaging features at thin-section CT, their predicted malignancy risk according to three major risk assessment models, minimum density analysis and contrast enhanced-CT in the relative subgroups of nodules which underwent such tests. Results Eleven nodules disappeared during follow-up, 29 showed volume loss and 16 had a VDT of 1121 days or higher. There were 48 nodules located peripherally (85.71%). Evaluation of the enhancement after contrast media (n=29) showed mean enhancement ±SD of 25.72±35.03 HU, median of 18 HU, ranging from 0 to 190 HU. Minimum density assessment (n=30) showed mean minimum HU ±SD of −28.27±47.86 HU, median of −25 HU, ranging from −144 to 68 HU. Mean malignancy risk ±SD was 15.05±26.69% for the BIMC model, 17.22±19.00% for the Mayo Clinic model and 19.07±33.16% for the Gurney’s model. Conclusions Our analysis suggests caution in using traditional knowledge when dealing with current small solid peripheral indeterminate SPNs and highlights how quantitative growth at follow-up should be the cornerstone of characterization.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Lung Neoplasms
multidetector computed tomography
lung neoplasms
Malignancy
Multidetector Computed Tomography
Solitary Pulmonary Nodule
03 medical and health sciences
0302 clinical medicine
medicine
Solitary pulmonary nodule
business.industry
Benignity
solitary pulmonary nodule
Retrospective cohort study
medicine.disease
030104 developmental biology
030220 oncology & carcinogenesis
Cohort
Original Article
Radiology
Risk assessment
Indeterminate
business
Lung cancer screening
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Polish Journal of Radiology
- Accession number :
- edsair.doi.dedup.....ccc393a2637ddce59ad47c45b10276d3