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Dysregulated expression of HOX and ParaHOX genes in human esophageal squamous cell carcinoma
- Source :
- Oncology Reports. 17(4):753-760
- Publication Year :
- 2007
- Publisher :
- Spandidos Publications, 2007.
-
Abstract
- Homeobox genes function as master regulators in embryonic morphogenesis. We hypothesized that homeobox genes are essential to maintain tissue- or organ-specificity even in adult body and that the dysregulated expression of homeobox genes results in tumor development and progression. To better understand the roles of homeobox genes in development and progression of esophageal cancer, we analyzed the expression patterns of 39 HOX genes and 4 ParaHOX (CDX1, CDX2, CDX4 and PDX1) genes in esophageal squamous cell carcinoma (ESCC) and normal esophageal mucosa tissues. A total of 48 primary ESCC tissues and 7 normal esophageal mucosa tissues were resected from patients who underwent radical surgery without any preoperative chemotherapy or radiotherapy. The expression of HOX and ParaHOX genes were analyzed by a quantitative real-time RT-PCR method and immunohistochemistry. The expression levels of 24 HOX genes, CDX1, CDX2 and PDX1 were significantly higher in ESCC compared to normal mucosa (p
- Subjects :
- Male
Cancer Research
Pathology
medicine.medical_specialty
Esophageal Neoplasms
ParaHox
Biology
real-time RT-PCR
homeobox gene
Embryonic morphogenesis
medicine
Humans
RNA, Messenger
esophageal cancer
Hox gene
CDX2
Aged
Aged, 80 and over
Homeodomain Proteins
Mucous Membrane
Genes, Homeobox
Cancer
General Medicine
Esophageal cancer
Middle Aged
medicine.disease
HOX
Immunohistochemistry
digestive system diseases
Gene Expression Regulation, Neoplastic
Oncology
embryonic structures
ParaHOX
Cancer research
Carcinoma, Squamous Cell
PDX1
Homeobox
Female
Subjects
Details
- Language :
- English
- ISSN :
- 1021335X
- Volume :
- 17
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Oncology Reports
- Accession number :
- edsair.doi.dedup.....ccbfbbd935a556708c77336d5a22b096