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Dysregulated expression of HOX and ParaHOX genes in human esophageal squamous cell carcinoma

Authors :
Masaki Miyamoto
Tetsuya Moriuchi
Jun-ichi Hamada
Toshimichi Asano
Shinya Hata
Satoshi Kondo
Osamu Takahashi
Yoko Takahashi
Motoki Abe
Mitsuhiro Tada
Source :
Oncology Reports. 17(4):753-760
Publication Year :
2007
Publisher :
Spandidos Publications, 2007.

Abstract

Homeobox genes function as master regulators in embryonic morphogenesis. We hypothesized that homeobox genes are essential to maintain tissue- or organ-specificity even in adult body and that the dysregulated expression of homeobox genes results in tumor development and progression. To better understand the roles of homeobox genes in development and progression of esophageal cancer, we analyzed the expression patterns of 39 HOX genes and 4 ParaHOX (CDX1, CDX2, CDX4 and PDX1) genes in esophageal squamous cell carcinoma (ESCC) and normal esophageal mucosa tissues. A total of 48 primary ESCC tissues and 7 normal esophageal mucosa tissues were resected from patients who underwent radical surgery without any preoperative chemotherapy or radiotherapy. The expression of HOX and ParaHOX genes were analyzed by a quantitative real-time RT-PCR method and immunohistochemistry. The expression levels of 24 HOX genes, CDX1, CDX2 and PDX1 were significantly higher in ESCC compared to normal mucosa (p

Details

Language :
English
ISSN :
1021335X
Volume :
17
Issue :
4
Database :
OpenAIRE
Journal :
Oncology Reports
Accession number :
edsair.doi.dedup.....ccbfbbd935a556708c77336d5a22b096