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Clinical and Prognostic Importance of Serotyping Mycobacterium avium-Mycobacterium intracellulare Complex Isolates in Human Immunodeficiency Virus-Negative Patients
- Source :
- Journal of Clinical Microbiology. 43:3150-3158
- Publication Year :
- 2005
- Publisher :
- American Society for Microbiology, 2005.
-
Abstract
- We studied whether the serotypes of Mycobacterium avium-Mycobacterium intracellulare complex (MAC) isolates determine the prognosis for pulmonary MAC disease. We prospectively monitored a cohort of 68 patients with pulmonary MAC disease for whom the serotype-specific glycopeptidolipids in isolates were identified using thin-layer chromatography and fast atom bombardment mass-spectrometry in 1990 and 1995. Serovar 4 Mycobacterium avium was detected in 40/68 patients (58.8%). Other serotypes were serotypes 1 (five cases), 6 (three cases), 8 (seven cases), 9 (three cases), 14 (four cases), and 16 (six cases). Patients with serovar 4 were significantly ( P < 0.01) younger (63.0 ± 9.8 years) than patients with other serotypes (71.8 ± 10.3). Patients who failed treatment had a significantly poorer prognosis than other patients. There were no cases of MAC-related death in the cured group. Chest radiographic findings progressively worsened in 36 (90%) of patients with serotype 4, and 14/36 died from respiratory failure caused by pulmonary Mycobacterium avium disease. The patients with serotype 4 had a significantly poorer prognosis than patients with other serotypes. These results show that both the outcome of chemotherapy and the serotypes of MAC isolates are important for assessing the prognosis of pulmonary MAC disease.
- Subjects :
- Male
Microbiology (medical)
Serotype
medicine.medical_specialty
Mycobacterium avium-intracellulare infection
Microbial Sensitivity Tests
Gastroenterology
Virus
HIV Seronegativity
Internal medicine
Immunopathology
medicine
Humans
Serotyping
Sida
Aged
Mycobacterium avium-intracellulare Infection
Aged, 80 and over
biology
Mycobacteriology and Aerobic Actinomycetes
Middle Aged
Mycobacterium avium Complex
Prognosis
biology.organism_classification
medicine.disease
Survival Analysis
Anti-Bacterial Agents
Radiography
Respiratory failure
Immunology
Female
Viral disease
Mycobacterium
Subjects
Details
- ISSN :
- 1098660X and 00951137
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Microbiology
- Accession number :
- edsair.doi.dedup.....ccb4de1f7029f1db506db35047538d55