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Multifunctional assembly of micrometer-sized colloids for cell sorting
- Source :
- Small (Weinheim an der Bergstrasse, Germany). 11(21)
- Publication Year :
- 2014
-
Abstract
- Compared to the extensively studied nanometer-sized colloids, less attention has been paid to the assembly of micrometer-sized colloids with multifunctional characteristics. To address this need, a bottom-up approach is developed for constructing self-assemblies of micrometer-sized magnetic colloids possessing multifunctionality, including magnetic, optical, and biological activities. Biotinylated oligo (p-phenylene vinylene) (OPV) derivatives are designed to mediate the self-assembly of streptavidin-modified magnetic beads. The optical element OPV derivatives provide a fluorescence imaging ability for tracing the assembly process. Target cells can be recognized and assembled by the colloidal assembly with bioactive element antibodies. The colloidal assembly reveals better cell isolation performance by its amplified magnetic response in comparison to monodisperse colloids. The self-assembly of micrometer-sized magnetic colloids through a combination of different functional ingredients to realize multifunction is conceptually simple and easy to achieve.
- Subjects :
- endocrine system
Fluorescence-lifetime imaging microscopy
Materials science
Dispersity
Nanotechnology
Cell Separation
complex mixtures
Biomaterials
Micrometre
Colloid
Magnetics
Humans
General Materials Science
Biotinylation
Cell isolation
Colloids
Particle Size
Microscopy, Confocal
Immunomagnetic Separation
digestive, oral, and skin physiology
General Chemistry
Magnetic response
Cell sorting
equipment and supplies
MCF-7 Cells
Polyvinyls
Self-assembly
Streptavidin
human activities
Biotechnology
Subjects
Details
- ISSN :
- 16136829
- Volume :
- 11
- Issue :
- 21
- Database :
- OpenAIRE
- Journal :
- Small (Weinheim an der Bergstrasse, Germany)
- Accession number :
- edsair.doi.dedup.....ccaf7fb14f16ec33fb20295af60ccf89