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Multifunctional assembly of micrometer-sized colloids for cell sorting

Authors :
Libing Liu
Bing Wang
Fengting Lv
Jiangyan Zhang
Chenyao Nie
Yongqiang Cheng
Shu Wang
Source :
Small (Weinheim an der Bergstrasse, Germany). 11(21)
Publication Year :
2014

Abstract

Compared to the extensively studied nanometer-sized colloids, less attention has been paid to the assembly of micrometer-sized colloids with multifunctional characteristics. To address this need, a bottom-up approach is developed for constructing self-assemblies of micrometer-sized magnetic colloids possessing multifunctionality, including magnetic, optical, and biological activities. Biotinylated oligo (p-phenylene vinylene) (OPV) derivatives are designed to mediate the self-assembly of streptavidin-modified magnetic beads. The optical element OPV derivatives provide a fluorescence imaging ability for tracing the assembly process. Target cells can be recognized and assembled by the colloidal assembly with bioactive element antibodies. The colloidal assembly reveals better cell isolation performance by its amplified magnetic response in comparison to monodisperse colloids. The self-assembly of micrometer-sized magnetic colloids through a combination of different functional ingredients to realize multifunction is conceptually simple and easy to achieve.

Details

ISSN :
16136829
Volume :
11
Issue :
21
Database :
OpenAIRE
Journal :
Small (Weinheim an der Bergstrasse, Germany)
Accession number :
edsair.doi.dedup.....ccaf7fb14f16ec33fb20295af60ccf89