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Standardization of a new non-invasive device for assessment of arterial stiffness in rats: Correlation with age-related arteries’ structure
- Source :
- MethodsX, Vol 7, Iss, Pp 100901-(2020), Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP, MethodsX, Scopus, Repositório Institucional da UNESP, Universidade Estadual Paulista (UNESP), instacron:UNESP
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- Pulse wave velocity (PWV) has become a gold standard index to quantify the stiffness of the aorta and is a predictor of cardiovascular events. A recent paper compared the pOpmètreⓇ, a device for measuring the finger-toe PWV, with other techniques and demonstrated its accuracy and validity. However, human devices do not allow the advancement of our knowledge on conditioning mechanisms. Based on its human validation, a new device, pOpetⓇ 1.0 system was designed for estimation of PWV in small animals and this present study aimed to standardize the pOpetⓇ 1.0 for estimation of arterial stiffness in rats, and to confirm its liability and stability as well as the reproducibility of assessments. Therefore several precautions were taken into consideration like as the correct position of the animal and photodiodes according to manufacturers’ suggestions. Results indicated that estimation of PWV through the new pOpetⓇ 1.0 device exhibits good internal consistency, stability and objectivity in all tests performed between days and evaluators. Importantly, data suggest for the first time that this new device is able to detect changes in arterial stiffness that are conditioned by age and pressure-related arterial remodeling. • This new pOpetⓇ device is able to detect changes in vessel structure. • This new pOpetⓇ device exhibits good internal consistency, stability and objectivity in all tests performed • Correct position of the animal and photodiodes are crucial to obtain a very stable signal.<br />Graphical abstract Image, graphical abstract
- Subjects :
- Femoral
Aging
Standardization
Computer science
Clinical Biochemistry
010501 environmental sciences
Collagen deposition
01 natural sciences
Correlation
03 medical and health sciences
COLÁGENO
medicine
lcsh:Science
Pulse wave velocity
Aorta
pOpetⓇ 1.0 system for small animals
030304 developmental biology
0105 earth and related environmental sciences
Carotid
0303 health sciences
Reproducibility
Non invasive
Stiffness
Gold standard (test)
Medicine and Dentistry
medicine.disease
Medical Laboratory Technology
Hypertension
Arterial stiffness
lcsh:Q
medicine.symptom
Biomedical engineering
Subjects
Details
- Language :
- English
- ISSN :
- 22150161
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- MethodsX
- Accession number :
- edsair.doi.dedup.....ccab03daa14003accc32aa1557642fb9