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Brief Note Low diversity of the major histocompatibility complex class II DRA gene in domestic goats (Capra hircus) in Southern China
- Source :
- Genetics and Molecular Research. 14:6925-6928
- Publication Year :
- 2015
- Publisher :
- Genetics and Molecular Research, 2015.
-
Abstract
- DRA encodes the alpha chain of the DR heterodimer, is closely linked to DRB and is considered almost monomorphic in major histocompatibility complex region. In this study, we identified the exon 2 of DRA to evaluate the immunogenetic diversity of Chinese south indigenous goat. Two single nucleotide polymorphisms in an untranslated region and one synonymous substitution in coding region were identified. These data suggest that high immunodiversity in native Chinese population.
- Subjects :
- Genetics
China
Polymorphism, Genetic
Goats
HLA-DR alpha-Chains
Single-nucleotide polymorphism
Exons
General Medicine
Biology
Major histocompatibility complex
Introns
Open Reading Frames
Exon
Untranslated Regions
Animals, Domestic
Capra hircus
biology.protein
Animals
Coding region
Synonymous substitution
Molecular Biology
Gene
Alpha chain
Subjects
Details
- ISSN :
- 16765680
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Genetics and Molecular Research
- Accession number :
- edsair.doi.dedup.....cc9fbea14eece2e35b8386d6b224224c