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Noninvasive Prenatal DNA Testing: The Vanguard of Genomic Medicine
- Source :
- Annu Rev Med
- Publication Year :
- 2017
- Publisher :
- Annual Reviews, 2017.
-
Abstract
- Noninvasive prenatal DNA testing is the vanguard of genomic medicine. In only four years, this screening test has revolutionized prenatal care globally and opened up new prospects for personalized medicine for the fetus. There are widespread implications for increasing the scope of human genetic variation that can be detected before birth, and for discovering more about maternofetal and placental biology. These include an urgent need to develop pretest education for all pregnant women and consistent post-test management recommendations for those with discordant test results. The reduction in invasive testing has had downstream effects on specialist training and caused many countries to re-examine their national approaches to prenatal screening. Finally, the accumulating datasets of genomic information on pregnant women and their fetuses raise ethical issues regarding consent for future data mining and intellectual property.
- Subjects :
- Health Knowledge, Attitudes, Practice
medicine.medical_specialty
DNA Mutational Analysis
Prenatal diagnosis
Prenatal care
Human genetic variation
Article
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
Prenatal Diagnosis
medicine
Vanguard
Data Mining
Humans
Genetic Testing
030212 general & internal medicine
Social Change
Intensive care medicine
Genetic testing
Chromosome Aberrations
Pregnancy
030219 obstetrics & reproductive medicine
medicine.diagnostic_test
business.industry
Genomics
General Medicine
medicine.disease
Intellectual Property
Biotechnology
Cell-free fetal DNA
Personalized medicine
business
Cell-Free Nucleic Acids
Subjects
Details
- ISSN :
- 1545326X and 00664219
- Volume :
- 68
- Database :
- OpenAIRE
- Journal :
- Annual Review of Medicine
- Accession number :
- edsair.doi.dedup.....cc9c7cc47c0bca888f05f51202264dfb