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Intra-laboratory assessment of a method for the detection of TiO2 nanoparticles present in sunscreens based on multi-detector asymmetrical flow field-flow fractionation
- Source :
- NANOIMPACT
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- In this study, an intra-laboratory assessment was carried out to establish the effectiveness of a method for the detection of TiO2 engineered nanoparticles (ENPs) present in sunscreen containing nano-scale TiO2 and a higher nanometer-range (approx. 200-500 nm) Ti02, as well as iron oxide particles. Three replicate measurements were performed on five separate days to generate the measurement uncertainties associated with the quantitative asymmetrical flow field-flow fractionation (AF4) measurement of the hydrodynamic radius r(h, mode1) (MALS), rh,,odei (ICP-MS), r(h, mode2) (ICP-MS), and calculated mass-based particle size distribution (d(10), d(50), d(90)). The validation study demonstrates that the analysis of TiO2 ENPs present in sunscreen by AF4 separation-multi detection produces quantitative data (mass-based particle size distribution) after applying the sample preparation method developed within the NanoDefine project with uncertainties based on the precision (u(IP)) of 3.9-8.8%. This method can, therefore, be considered as the method with a good precision. Finally, the bias data shows that the trueness of the method (u(t) = 5.5-52%) can only be taken as a proxy due to the lack of a sunscreen standard containing certified TiO2 ENPs.
- Subjects :
- Risk
EXTRACTION
Technology and Engineering
Materials Science (miscellaneous)
Asymmetrical Flow Field-Flow Fractionation
Sample preparation
Multiangle light scattering
Analytical chemistry
02 engineering and technology
Fractionation
010501 environmental sciences
01 natural sciences
VALIDATION
FOOD
ICP-MS
Safety, Risk, Reliability and Quality
Inductively coupled plasma mass spectrometry
Multi angle light scattering
0105 earth and related environmental sciences
NANOMATERIALS
Asymmetrical flow field-flow fractionation
Environmental and Occupational Health
Public Health, Environmental and Occupational Health
Replicate
TiO2 nanoparticles in sunscreen
In-house validation
021001 nanoscience & nanotechnology
Multi detector
Chemistry
SIZE
Physics and Astronomy
Reliability and Quality
Particle-size distribution
Public Health
Safety
0210 nano-technology
Safety Research
Subjects
Details
- ISSN :
- 24520748
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- NanoImpact
- Accession number :
- edsair.doi.dedup.....cc99a1d459eff3fb07c4925403e1ad16