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Bona Fide Tumor Suppressor Genes Hypermethylated in Melanoma: A Narrative Review
- Source :
- International Journal of Molecular Sciences, Vol 22, Iss 10674, p 10674 (2021), International Journal of Molecular Sciences
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Loss-of-function events in tumor suppressor genes (TSGs) contribute to the development and progression of cutaneous malignant melanoma (CMM). Epigenetic alterations are the major mechanisms of TSG inactivation, in particular, silencing by promoter CpG-island hypermethylation. TSGs are valuable tools in diagnosis and prognosis and, possibly, in future targeted therapy. The aim of this narrative review is to outline bona fide TSGs affected by promoter CpG-island hypermethylation and their functional role in the progression of CMM. We conducted a systematic literature review to identify studies providing evidence of bona fide TSGs by cell line or animal experiments. We performed a broad first search and a gene-specific second search, supplemented by reference checking. We included studies describing bona fide TSGs in CMM with promoter CpG-island hypermethylation in which inactivating mechanisms were reported. We extracted data about protein role, pathway, experiments conducted to meet the bona fide criteria and hallmarks of cancer acquired by TSG inactivation. A total of 24 studies were included, describing 24 bona fide TSGs silenced by promoter CpG-island hypermethylation in CMM. Their effect on cell proliferation, apoptosis, growth, senescence, angiogenesis, migration, invasion or metastasis is also described. These data give further insight into the role of TSGs in the progression of CMM. ispartof: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES vol:22 issue:19 ispartof: location:Switzerland status: published
- Subjects :
- Epigenomics
QH301-705.5
medicine.medical_treatment
Review
Biology
Catalysis
Epigenesis, Genetic
Targeted therapy
law.invention
Metastasis
Inorganic Chemistry
law
medicine
Animals
Humans
Gene silencing
Genes, Tumor Suppressor
Epigenetics
Physical and Theoretical Chemistry
Biology (General)
Melanoma
Molecular Biology
QD1-999
Spectroscopy
Organic Chemistry
Cancer
General Medicine
DNA Methylation
medicine.disease
Computer Science Applications
Gene Expression Regulation, Neoplastic
hypermethylation
Chemistry
DNA methylation
Cancer research
Suppressor
CpG Islands
tumor suppressor genes
epigenetic
Subjects
Details
- Language :
- English
- ISSN :
- 16616596 and 14220067
- Volume :
- 22
- Issue :
- 10674
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....cc882c32aadaddb509cb027a6feaac2d