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Neonatal Respiratory Diseases in the Newborn Infant: Novel Insights from Stable Isotope Tracer Studies
- Source :
- Neonatology. 109:325-333
- Publication Year :
- 2016
- Publisher :
- S. Karger AG, 2016.
-
Abstract
- Respiratory distress syndrome is a common problem in preterm infants and the etiology is multifactorial. Lung underdevelopment, lung hypoplasia, abnormal lung water metabolism, inflammation, and pulmonary surfactant deficiency or disfunction play a variable role in the pathogenesis of respiratory distress syndrome. High-quality exogenous surfactant replacement studies and studies on surfactant metabolism are available; however, the contribution of surfactant deficiency, alteration or dysfunction in selected neonatal lung conditions is not fully understood. In this article, we describe a series of studies made by applying stable isotope tracers to the study of surfactant metabolism and lung water. In a first set of studies, which we call ‘endogenous studies', using stable isotope-labelled intravenous surfactant precursors, we showed the feasibility of measuring surfactant synthesis and kinetics in infants using several metabolic precursors including plasma glucose, plasma fatty acids and body water. In a second set of studies, named ‘exogenous studies', using stable isotope-labelled phosphatidylcholine tracer given endotracheally, we could estimate surfactant disaturated phosphatidylcholine pool size and half-life. Very recent studies are focusing on lung water and on the endogenous biosynthesis of the surfactant-specific proteins. Information obtained from these studies in infants will help to better tailor exogenous surfactant treatment in neonatal lung diseases.
- Subjects :
- Surfactant kinetics
Congenital diaphragmatic hernia
Pediatrics
Surfactant metabolism
Congenital
chemistry.chemical_compound
0302 clinical medicine
Isotopes
Pulmonary surfactant
Meconium aspiration syndrome
030212 general & internal medicine
Respiratory system
Lung
Stable isotopes
Hernias
Respiratory distress
Lung water
Perinatology and Child Health
medicine.anatomical_structure
Anesthesia
Phosphatidylcholines
Infant, Premature
medicine.medical_specialty
Disaturated phosphatidylcholine
Newborn infant
Phosphatidylcholine
Respiratory distress syndrome
Hernias, Diaphragmatic, Congenital
Humans
Infant, Newborn
Meconium Aspiration Syndrome
Pneumonia
Pulmonary Surfactants
Respiratory Distress Syndrome, Newborn
03 medical and health sciences
030225 pediatrics
Internal medicine
medicine
Premature
Developmental Biology
Pediatrics, Perinatology and Child Health
business.industry
Infant
Newborn
medicine.disease
Endocrinology
chemistry
business
Diaphragmatic
Subjects
Details
- ISSN :
- 16617819 and 16617800
- Volume :
- 109
- Database :
- OpenAIRE
- Journal :
- Neonatology
- Accession number :
- edsair.doi.dedup.....cc83fe3494d46774648570a71a4c3cd5