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Cisplatin and carboplatin mediated release of cytolytic factors in murine peritoneal macrophages in vitro
- Source :
- Anti-Cancer Drugs. 5:615-622
- Publication Year :
- 1994
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1994.
-
Abstract
- The anticancer drugs cisplatin and carboplatin have been shown to activate murine peritoneal macrophages in vivo and in vitro. These activated macrophages have enhanced tumoricidal activity mediated by extension and contact formation with the tumor cells leading to an increase and transfer of lysosomes with eventual lysis of the tumor cells. Cisplatin (10 micrograms/ml) or carboplatin (50 micrograms/ml) for 2 and 24 h treatment of macrophages in vitro, in addition, show a significant increase in the release of various cytolytic factors, like hydrogen peroxide, superoxide anion, interleukin-1 alpha, lysozyme and beta-N-hexoseaminidase, that are also responsible for the destruction of tumor cells.
- Subjects :
- Cancer Research
Lysis
Cell Count
Carboplatin
Mice
chemistry.chemical_compound
Superoxides
In vivo
Tumor Cells, Cultured
medicine
Animals
Pharmacology (medical)
Sarcoma 180
Cells, Cultured
Pharmacology
Cisplatin
Superoxide
Hydrogen Peroxide
Macrophage Activation
In vitro
Cytolysis
Hexosaminidases
Oncology
chemistry
Immunology
Macrophages, Peritoneal
Cancer research
Muramidase
Lysozyme
Interleukin-1
medicine.drug
Subjects
Details
- ISSN :
- 09594973
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Anti-Cancer Drugs
- Accession number :
- edsair.doi.dedup.....cc7e21634a415027fd1dc85f50aa901b