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Deformation-based Statistical Shape Analysis of the Corpus Callosum in Mild Cognitive Impairment and Alzheimer’s Disease
- Source :
- Current Alzheimer Research. 15:1151-1160
- Publication Year :
- 2018
- Publisher :
- Bentham Science Publishers Ltd., 2018.
-
Abstract
- Objective: In this study, we investigated the influence that the pathology of Alzheimer’s disease (AD) exerts upon the corpus callosum (CC) using a total of 325 mild cognitive impairment (MCI) subjects, 155 AD subjects, and 185 healthy control (HC) subjects. Method: Regionally-specific morphological CC abnormalities, as induced by AD, were quantified using a large deformation diffeomorphic metric curve mapping based statistical shape analysis pipeline. We also quantified the association between the CC shape phenotype and two cognitive measures; the Mini Mental State Examination (MMSE) and the Alzheimer’s Disease Assessment Scale-Cognitive Behavior Section (ADAS-cog). To identify AD-relevant areas, CC was sub-divided into three subregions; the genu, body, and splenium (gCC, bCC, and sCC). Results: We observed significant shape compressions in AD relative to that in HC, mainly concentrated on the superior part of CC, across all three sub-regions. The HC-vs-MCI shape abnormalities were also concentrated on the superior part, but mainly occurred on bCC and sCC. The significant MCI-vs-AD shape differences, however, were only detected in part of sCC. In the shape-cognition association, significant negative correlations to ADAS-cog were detected for shape deformations at regions belonging to gCC and sCC and significant positive correlations to MMSE at regions mainly belonging to sCC. Conclusion: Our results suggest that the callosal shape deformation patterns, especially those of sCC, linked tightly to the cognitive decline in AD, and are potentially a powerful biomarker for monitoring the progression of AD.
- Subjects :
- Male
0301 basic medicine
Pathology
medicine.medical_specialty
Splenium
Disease
Corpus callosum
Corpus Callosum
03 medical and health sciences
0302 clinical medicine
Alzheimer Disease
Image Processing, Computer-Assisted
Humans
Medicine
Cognitive Dysfunction
Cognitive decline
Correlation of Data
Aged
Aged, 80 and over
Mini–Mental State Examination
medicine.diagnostic_test
business.industry
Statistical shape analysis
Cognition
Magnetic Resonance Imaging
030104 developmental biology
Neurology
Female
Neurology (clinical)
Mental Status Schedule
business
030217 neurology & neurosurgery
Shape analysis (digital geometry)
Subjects
Details
- ISSN :
- 15672050
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Current Alzheimer Research
- Accession number :
- edsair.doi.dedup.....cc7b353272d5102468a3c327064be335