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A review of bioanalytical methods for chronic lymphocytic leukemia drugs and metabolites in biological matrices
- Source :
- Biomedical Chromatography. 34
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- Quantitation of drugs used for the treatment of chronic lymphocytic leukemia in various biological matrices during both pre-clinical and clinical developments is very important, often in routine therapeutic drug monitoring. The first developed methods for quantitation were traditionally done on LC in combination with either UV or fluorescence detection. However, the emergence of LC with mass spectrometry in tandem in early 1990s has revolutionized the quantitation as it has provided better sensitivity and selectivity within a shorter run time; therefore it has become the choice of method for the analysis of various drugs. In this article, an overview of various bioanalytical methods (HPLC or LC-MS/MS) for the quantification of drugs for the treatment of chronic lymphocytic leukemia, along with applicability of these methods, is given.
- Subjects :
- Bendamustine
Bioanalysis
Chronic lymphocytic leukemia
Clinical Biochemistry
Antineoplastic Agents
030226 pharmacology & pharmacy
01 natural sciences
Biochemistry
Analytical Chemistry
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Tandem Mass Spectrometry
Drug Discovery
medicine
Humans
Cladribine
Molecular Biology
Pharmacology
Chromatography
medicine.diagnostic_test
Chlorambucil
Chemistry
010401 analytical chemistry
General Medicine
medicine.disease
Leukemia, Lymphocytic, Chronic, B-Cell
0104 chemical sciences
Therapeutic drug monitoring
Ibrutinib
Drug Monitoring
Idelalisib
Chromatography, Liquid
medicine.drug
Subjects
Details
- ISSN :
- 10990801 and 02693879
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Biomedical Chromatography
- Accession number :
- edsair.doi.dedup.....cc7505e97624d73ed1da77581f51b5ac