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Initial experience with the use of tris-acryl gelatin microspheres for transcatheter arterial embolization for enlarged polycystic liver
- Source :
- Clinical and experimental nephrology. 23(6)
- Publication Year :
- 2018
-
Abstract
- To assess the safety and effectiveness of transcatheter arterial embolization (TAE) with tris-acryl gelatin microspheres for patients with symptomatic enlarged polycystic liver disease (PCLD). This prospective study was approved by our hospital’s institutional review board and planned for patients with symptoms related to enlarged PCLD, such as distended abdomen, gastrointestinal obstruction and abdominal pain. Hemi-hepatic embolization with tris-acryl gelatin microspheres was performed in the hepatic artery supplying the hepatic lobe that showed the predominant presence of cysts. Each patient underwent an assessment of liver function, a questionnaire survey about symptoms, measurement of the estimated volume of the whole liver before and after TAE, and an assessment of complications associated with TAE. Five patients (four females, one male; mean age 52.6 ± 9.1 years) were treated. All five patients successfully completed TAE. The left lobe was treated in three patients and the right in two. After TAE, post-embolization syndrome and transient elevation of white blood cells, aspartate aminotransferase, and alanine aminotransferase occurred in all patients, but none developed hepatic insufficiency or severe complications. The mean whole liver volume was 7406 ± 2323 mL before TAE, and 6995 ± 2139 mL (95.1 ± 5.2% of the pre-therapeutic value) at 3 months and 6855 ± 2246 mL (93.3 ± 9.7%) at 12 months after TAE. Three of the five patients reported an improvement of clinical symptoms within 12 months after TAE. TAE with microspheres can be a safe and effective treatment for symptomatic enlarged PCLD.
- Subjects :
- Adult
Male
medicine.medical_specialty
Abdominal pain
Physiology
medicine.medical_treatment
030232 urology & nephrology
Acrylic Resins
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Physiology (medical)
medicine
Humans
Embolization
Prospective Studies
business.industry
Cysts
Polycystic liver disease
Arterial Embolization
Liver Diseases
Middle Aged
medicine.disease
Embolization, Therapeutic
Surgery
medicine.anatomical_structure
Nephrology
Abdomen
Gelatin
Female
Radiology
Liver function
medicine.symptom
business
Tris-acryl Gelatin Microspheres
Artery
Subjects
Details
- ISSN :
- 14377799
- Volume :
- 23
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Clinical and experimental nephrology
- Accession number :
- edsair.doi.dedup.....cc6b6980d4ea49622983555fc8afa5a2