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Correlations between limbic white matter and cognitive function in temporal lobe epilepsy, preliminary findings
- Source :
- Frontiers in Aging Neuroscience, Vol 6 (2014), Frontiers in Aging Neuroscience
- Publication Year :
- 2014
- Publisher :
- Frontiers Media S.A., 2014.
-
Abstract
- The limbic system is presumed to have a central role in cognitive performance, in particular memory. The purpose of this study was to investigate the relationship between limbic white matter microstructure and neuropsychological function in temporal lobe epilepsy (TLE) patients using diffusion tensor imaging (DTI). Twenty-one adult TLE patients, including seven non-lesional (nlTLE) and fourteen with unilateral mesial temporal sclerosis (uTLE), were studied with both DTI and hippocampal T2 relaxometry. Correlations were performed between fractional anisotropy (FA) of the bilateral fornix and cingulum, hippocampal T2, neuropsychological tests. Positive correlations were observed in the whole group for the left fornix and Processing Speed Index. In contrast, memory tests did not show significant correlations with DTI findings. Subgroup analysis demonstrated an association between the left fornix and Processing Speed in nlTLE but not uTLE. No correlations were observed between hippocampal T2 and test scores in either the TLE group as a whole or after subgroup analysis. Our findings suggest that integrity of the left fornix specifically is an important anatomical correlate of cognitive function in TLE patients, in particular patients with nlTLE.
- Subjects :
- Aging
Diffusion tensor imaging (DTI)
mesial temporal sclerosis
Cognitive Neuroscience
behavioral disciplines and activities
Temporal lobe
lcsh:RC321-571
Limbic system
Temporal Lobe Epilepsy
Fractional anisotropy
medicine
Cingulum (brain)
processing speed
Neuropsychological assessment
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Original Research
medicine.diagnostic_test
temporal-lobe epilepsy
Fornix
Neuropsychology
diffusion tensor imaging
neuropsychological assessment
medicine.anatomical_structure
nervous system
Psychology
Neuroscience
psychological phenomena and processes
Diffusion MRI
Subjects
Details
- Language :
- English
- ISSN :
- 16634365
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Frontiers in Aging Neuroscience
- Accession number :
- edsair.doi.dedup.....cc4fd11205a856bf925c0301f59e0025