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Biliary atresia: A comprehensive review
- Source :
- Journal of Autoimmunity. 73:1-9
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Biliary atresia presents as an obliterative cholangiopathy with neonatal jaundice and pale stools. The disease exhibits aetiological heterogeneity with a multiplicity of potential causative factors, both developmental and environmental. A number of clinical variants making up a minority of all cases can be defined relatively precisely which match suggested aetiology better although in most it still remains speculative. These include the syndromic form (BASM), the cystic form and those associated with CMV IgM antibodies. We review not only the clinical evidence for a developmental or an immune-mediated aetiology perhaps triggered by perinatal viral exposure but also several other recently suggested concepts such as microchimerism, gene susceptibility and environmental toxins.
- Subjects :
- Biopsy
T-Lymphocytes
Immunology
Cytomegalovirus
Disease
medicine.disease_cause
Chimerism
03 medical and health sciences
0302 clinical medicine
Liver Function Tests
Biliary Atresia
Biliary atresia
030225 pediatrics
medicine
Humans
Immunology and Allergy
Genetic Predisposition to Disease
Ultrasonography
medicine.diagnostic_test
business.industry
Incidence
Infant
Microchimerism
Environmental Exposure
Environmental exposure
Jaundice
medicine.disease
Immunity, Humoral
Immunoglobulin M
Liver
Etiology
030211 gastroenterology & hepatology
Bile Ducts
medicine.symptom
business
Liver function tests
Subjects
Details
- ISSN :
- 08968411
- Volume :
- 73
- Database :
- OpenAIRE
- Journal :
- Journal of Autoimmunity
- Accession number :
- edsair.doi.dedup.....cc3859b5977efec40d7ec00e36987805