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Inhibitory KIR2DL2 Gene: Risk for Deep Endometriosis in Euro-descendants
- Source :
- Reproductive Sciences. 28:291-304
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Endometriosis (EDT) is an inflammatory disease characterized by implantation/growth of endometrial tissue, glands, and/or stroma, outside the uterus. Reduced NK cell cytotoxic activity has been implicated in its pathogenesis, together with other immunologic alterations. We investigated the influence of KIR gene polymorphisms and their HLA ligand combinations in deep endometriosis (DE) susceptibility. One hundred sixty women with a histological diagnosis of DE and 202 control women without the disease, who underwent laparoscopy, were enrolled. The DE group was subdivided into initial (I/II; n = 60) and advanced stages (III/IV, n = 100). KIR and HLA class I gene polymorphisms were typed by PCR-SSP and sequence-based-typing (SBT), respectively. We observed a significant association of KIR2DL2, an inhibitory gene of B haplotype, conferring risk for DE in Euro-descendants. Positive associations of Bx haplotype and centromeric AB segments were also found. However, no association with KIR-HLA ligand combination was observed. Our data suggest KIR2DL2 gene to be a relevant factor favoring NK inhibition in DE in Euro-descendants, contributing to the defective NK cytotoxic activity and impaired clearance of ectopic endometrial cells in the disease.
- Subjects :
- Adult
0301 basic medicine
Endometriosis
Uterus
Human leukocyte antigen
Polymorphism, Single Nucleotide
Risk Assessment
Severity of Illness Index
White People
Pathogenesis
Young Adult
03 medical and health sciences
0302 clinical medicine
Stroma
Risk Factors
medicine
Humans
Cytotoxic T cell
Genetic Predisposition to Disease
Gene
Genetic Association Studies
030219 obstetrics & reproductive medicine
business.industry
Haplotype
Obstetrics and Gynecology
Middle Aged
medicine.disease
Killer Cells, Natural
Phenotype
030104 developmental biology
medicine.anatomical_structure
Haplotypes
Case-Control Studies
Receptors, KIR2DL2
Immunology
Female
business
Brazil
Subjects
Details
- ISSN :
- 19337205 and 19337191
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Reproductive Sciences
- Accession number :
- edsair.doi.dedup.....cc2ef2928a4ee30f3cea45bbf5cb22c5