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MicroRNAs and nervous system diseases: network insights and computational challenges
- Source :
- Briefings in Bioinformatics. 21:863-875
- Publication Year :
- 2019
- Publisher :
- Oxford University Press (OUP), 2019.
-
Abstract
- The nervous system is one of the most complex biological systems, and nervous system disease (NSD) is a major cause of disability and mortality. Extensive evidence indicates that numerous dysregulated microRNAs (miRNAs) are involved in a broad spectrum of NSDs. A comprehensive review of miRNA-mediated regulatory will facilitate our understanding of miRNA dysregulation mechanisms in NSDs. In this work, we summarized currently available databases on miRNAs and NSDs, star NSD miRNAs, NSD spectrum width, miRNA spectrum width and the distribution of miRNAs in NSD sub-categories by reviewing approximately 1000 studies. In addition, we characterized miRNA–miRNA and NSD–NSD interactions from a network perspective based on miRNA–NSD benchmarking data sets. Furthermore, we summarized the regulatory principles of miRNAs in NSDs, including miRNA synergistic regulation in NSDs, miRNA modules and NSD modules. We also discussed computational challenges for identifying novel miRNAs in NSDs. Elucidating the roles of miRNAs in NSDs from a network perspective would not only improve our understanding of the precise mechanism underlying these complex diseases, but also provide novel insight into the development, diagnosis and treatment of NSDs.
- Subjects :
- 0303 health sciences
Mechanism (biology)
Computer science
Computational Biology
Computational biology
MicroRNAs
03 medical and health sciences
Broad spectrum
0302 clinical medicine
Gene Expression Regulation
microRNA
Humans
Nervous System Diseases
Molecular Biology
030217 neurology & neurosurgery
030304 developmental biology
Information Systems
Subjects
Details
- ISSN :
- 14774054 and 14675463
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Briefings in Bioinformatics
- Accession number :
- edsair.doi.dedup.....cc28810be9bc9d931e837868157a9f2e