Back to Search
Start Over
Longitudinal assessment of quantitative ultra-widefield ischaemic and vascular parameters in sickle cell retinopathy
- Source :
- British Journal of Ophthalmology. 106:251-255
- Publication Year :
- 2020
- Publisher :
- BMJ, 2020.
-
Abstract
- PurposeTo evaluate longitudinal quantitative ischaemic and vasculature parameters, including ischaemic index, vessel area, length and geodesic distance in sickle cell retinopathy (SCR) on ultra-widefield fluorescein angiography (UWFA).MethodsOptimal UWFA images from two longitudinal timepoints of 74 eyes from 45 patients with SCR were aligned and a common region of interest was determined. A deep-learning augmented ischaemia and vascular segmentation platform was used for feature extraction. Geodesic distance maps demonstrating the shortest distance within the vascular masks from the centre of the optic disc were created. Ischaemic index, vessel area, vessel length and geodesic distance were measured. Paired t-test and linear mixed effect model analysis were performed.ResultsOverall, 25 (44 eyes) patients with HbSS, 14 (19 eyes) with HbSC, 6 (11 eyes) with HbSthal and other genotypes were included. Mean age was 40.1±11.0 years. Mean time interval between two UWFA studies was 23.0±15.1 months (range: 3–71.3). Mean panretinal ischaemic index increased from 10.0±7.2% to 10.9±7.3% (pConclusionLongitudinal ischaemic index and retinal vascular parameter measurements demonstrate statistically significant progression in SCR. The clinical significance of these relatively small magnitude changes remains unclear but may provide insights into the progression of retinal ischaemia in SCR.
- Subjects :
- Adult
medicine.medical_specialty
Visual Acuity
Ischemia
Anemia, Sickle Cell
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Retinal Diseases
Region of interest
Ophthalmology
medicine
Humans
Clinical significance
Sickle cell retinopathy
Fluorescein Angiography
Retina
Diabetic Retinopathy
medicine.diagnostic_test
business.industry
Retinal Vessels
Retinal
Middle Aged
medicine.disease
Fluorescein angiography
Sensory Systems
medicine.anatomical_structure
chemistry
business
Tomography, Optical Coherence
Optic disc
Subjects
Details
- ISSN :
- 14682079 and 00071161
- Volume :
- 106
- Database :
- OpenAIRE
- Journal :
- British Journal of Ophthalmology
- Accession number :
- edsair.doi.dedup.....cc0eaad0a6febb5777e7be0eecca142b