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From prenatal genomic diagnosis to fetal personalized medicine: progress and challenges
- Source :
- Nature Medicine. 18:1041-1051
- Publication Year :
- 2012
- Publisher :
- Springer Science and Business Media LLC, 2012.
-
Abstract
- Thus far, the focus of personalized medicine has been the prevention and treatment of conditions that affect adults. Although advances in genetic technology have been applied more frequently to prenatal diagnosis than to fetal treatment, genetic and genomic information is beginning to influence pregnancy management. Recent developments in sequencing the fetal genome combined with progress in understanding fetal physiology using gene expression arrays indicate that we could have the technical capabilities to apply an individualized medicine approach to the fetus. Here I review recent advances in prenatal genetic diagnostics, the challenges associated with these new technologies and how the information derived from them can be used to advance fetal care. Historically, the goal of prenatal diagnosis has been to provide an informed choice to prospective parents. We are now at a point where that goal can and should be expanded to incorporate genetic, genomic and transcriptomic data to develop new approaches to fetal treatment.
- Subjects :
- Fetus
Pregnancy
medicine.medical_specialty
business.industry
Emerging technologies
Genomics
Prenatal diagnosis
General Medicine
medicine.disease
Precision medicine
Article
General Biochemistry, Genetics and Molecular Biology
Fetal Diseases
Genetic engineering
Prenatal Diagnosis
Immunology
medicine
Humans
Personalized medicine
Precision Medicine
Transcriptome
business
Intensive care medicine
Subjects
Details
- ISSN :
- 1546170X and 10788956
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Nature Medicine
- Accession number :
- edsair.doi.dedup.....cc0a5fe74b14238c1bc9858afb8fc70a