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Arterial hypertension after age 65 : from epidemiology and pathophysiology to therapy Do we know where we stand?
- Publication Year :
- 2018
-
Abstract
- Arterial hypertension is a prevalent disease with great harming potential. After the age of 55 years the remaining lifetime risk of hypertension amounts to 90%. Despite the constant advances some important issues such as the cut-off blood pressure for the initiation of antihypertensive therapy or the therapeutic goal are debated. In this review, we present - based on the available literature - the current concepts concerning the pathophysiology, epi-demiology and antihypertensive therapy in patients aged 65 years or older. The pathophysiology of hypertension in older patients in principle rests on stiffening of large conduit arteries, which leads to greater systolic and lower diastolic blood pressure. This in most older patients results in isolated systolic hypertension. Additionally most of these patients have low-renin hypertension. Data from large-scale clinical trials indicate that therapy of such individuals with thiazide-like diuretics and long-acting dihydropiridine calcium channel blockers as first-line medications reduces risk of complications. Based on results of recently published trials, meta-analyses, and prospective observations, the optimal on-treatment blood pressure values for most older hypertensive patients should be set within the 130-139 mmHg range. At present, lower values of standard office blood pressure in this group of patients have not been shown to be associ-ated with additional benefits, and may be associated with a greater risk of adverse events. In conclusion, we recommend that for most patients aged 65 years or more, standard office systolic blood pressure should be cautiously reduced to within 140 and 130 mmHg, preferably with a thiazide-like diuretic, long acting dihydropiridine calcium channel blocker or their combination.
- Subjects :
- Male
030213 general clinical medicine
medicine.medical_specialty
medicine.drug_class
medicine.medical_treatment
Vasodilator Agents
Blood Pressure
Calcium channel blocker
Disease
Thiazides
03 medical and health sciences
0302 clinical medicine
Internal medicine
Epidemiology
medicine
Humans
Adverse effect
Diuretics
Antihypertensive Agents
Aged
business.industry
Middle Aged
medicine.disease
Clinical trial
Primary Prevention
Blood pressure
Cardiovascular Diseases
030220 oncology & carcinogenesis
Pathophysiology of hypertension
Hypertension
Cardiology
Female
Diuretic
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....cbffbdde78c352a70155bb0a8bd4f611