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Melatonin delays ovarian aging in mice by slowing down the exhaustion of ovarian reserve
- Source :
- Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021), Communications Biology
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- Studies have shown that melatonin (MLT) can delay ovarian aging, but the mechanism has not been fully elucidated. Here we show that granulosa cells isolated from mice follicles can synthesize MLT; the addition of MLT in ovary culture system inhibited follicle activation and growth; In vivo experiments indicated that injections of MLT to mice during the follicle activation phase can reduce the number of activated follicles by inhibiting the PI3K-AKT-FOXO3 pathway; during the early follicle growth phase, MLT administration suppressed follicle growth and atresia, and multiple pathways involved in folliculogenesis, including PI3K-AKT, were suppressed; MLT deficiency in mice increased follicle activation and atresia, and eventually accelerated age-related fertility decline; finally, we demonstrated that prolonged high-dose MLT intake had no obvious adverse effect. This study presents more insight into the roles of MLT in reproductive regulation that endogenous MLT delays ovarian aging by inhibiting follicle activation, growth and atresia.<br />Chan Yang, Qinghua Liu, et al. use in vitro and SNAT-null mouse models to investigate the role of melatonin in ovarian aging. Their results suggest that melatonin can delay ovarian aging by inhibiting follicle activation, growth and atresia, providing more insight into how melatonin impacts reproduction.
- Subjects :
- 0301 basic medicine
Endocrine reproductive disorders
medicine.medical_specialty
Aging
endocrine system
Amino Acid Transport System A
QH301-705.5
Medicine (miscellaneous)
Endogeny
Ovary
Biology
General Biochemistry, Genetics and Molecular Biology
Article
Melatonin
03 medical and health sciences
Follicle
Mice
0302 clinical medicine
Ovarian Follicle
In vivo
Internal medicine
medicine
Animals
Biology (General)
Ovarian reserve
Ovarian Reserve
Animal breeding
Mice, Knockout
Reproduction
medicine.disease
Mice, Inbred C57BL
030104 developmental biology
Endocrinology
medicine.anatomical_structure
Fertility
Atresia
Female
Folliculogenesis
General Agricultural and Biological Sciences
030217 neurology & neurosurgery
hormones, hormone substitutes, and hormone antagonists
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 23993642
- Volume :
- 4
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Communications Biology
- Accession number :
- edsair.doi.dedup.....cbdb1a611003db0f1008ff5d41683f08