Histological and histochemical changes in placenta of diabetic pregnant females and its comparision with normal placenta

Objective To investigate the histological and histochemical changes in placenta of diabetic pregnant females and compare them with normal placenta. Methods The histological and histochemical features of 60 placenta, 30 obtained from normal pregnant females and 30 from diabetic pregnant females, were studied. These placenta were obtained from Department of Obstetrics and Gynaecology, GSVM Medical College Kanpur and ERA's Lucknow Medical College and Hospital Lucknow. Results On histological examination, the diabetic placenta showed increased syncytial knots, fibrinoid necrosis, trophoblastic basement membrane thickening, villous stromal fibrosis, villous oedema, crowding of villi, thickening of vessel wall and fibrin deposition. On histochemical study it was found that the PAS reactivity was stronger in diabetic placenta as compared to normal. Sudan Black reactivity was higher among diabetic placenta in comparison to normal placenta. Conclusions It is concluded that distinct histological and histochemical changes could be seen in placenta of diabetic pregnant females.