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Kidney function, gait pattern and fall in the general population: a cohort study
- Source :
- Nephrology Dialysis Transplantation, 33(12), 2165-2172. Oxford University Press
- Publication Year :
- 2018
-
Abstract
- Background Gait disturbance is proposed as a mechanism for higher risk of fall in kidney disease patients. We investigated the association of kidney function with gait pattern in the general population and tested whether the association between impaired kidney function and fall is more pronounced in subjects with lower gait function. Methods We included 1430 participants (mean age: 60 years) from the Rotterdam Study. Kidney function was assessed using estimated glomerular filtration rate (eGFR) and albumin-to-creatinine ratio (ACR). We assessed global gait, gait velocity and seven independent gait domains: Rhythm, Phases, Variability, Pace, Tandem, Turning and Base of Support. Regression models adjusted for cardiometabolic and neurological factors were used. We evaluated whether participants with impaired kidney function and impaired gait fell more in the previous year. Results The study population had a median (interquartile range) ACR of 3.6 (2.5-6.2) mg/g and mean ± SD eGFR of 87.6 ± 15 mL/min/1.73 m2. Higher ACR and lower eGFR were associated with lower global gait score [per doubling of ACR: -0.10, 95% confidence interval (CI): -0.14 to -0.06, and per SD eGFR:-0.09, 95% CI: -0.14 to -0.03] and slower gait speed (ACR: -1.44 cm/s, CI: -2.12 to -0.76; eGFR: -1.55 cm/s, CI: -2.43 to -0.67). Worse kidney function was associated with lower scores in Variability domain. The association between impaired kidney function and history of fall was present only in participants with lower gait scores [odds ratio (95% CI): ACR: 1.34 (1.09-1.65); eGFR: 1.58 (1.07-2.33)]. Conclusions We observed a graded association between lower kidney function and impaired gait suggesting that individuals with decreased kidney function, even at an early stage, need to be evaluated for gait abnormalities and might benefit from fall prevention programmes.
- Subjects :
- Male
medicine.medical_specialty
Population
030232 urology & nephrology
Renal function
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Interquartile range
Risk Factors
Internal medicine
medicine
Odds Ratio
Albuminuria
Humans
030212 general & internal medicine
Renal Insufficiency
education
Gait
Aged
Netherlands
Inflammation
Metabolic Syndrome
Transplantation
education.field_of_study
Gait Disturbance
business.industry
Odds ratio
Middle Aged
medicine.disease
Preferred walking speed
Nephrology
Cardiovascular Diseases
Cardiology
Accidental Falls
Female
Nervous System Diseases
business
human activities
Kidney disease
Glomerular Filtration Rate
Subjects
Details
- ISSN :
- 09310509
- Database :
- OpenAIRE
- Journal :
- Nephrology Dialysis Transplantation, 33(12), 2165-2172. Oxford University Press
- Accession number :
- edsair.doi.dedup.....cbba3f37b305789cb5f66d34216c01ab