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Mitophagy contributes to endothelial adaptation to simulated microgravity
- Source :
- FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 34(1)
- Publication Year :
- 2019
-
Abstract
- Exposure to real or simulated microgravity is sensed as a stress by mammalian cells, which activate a complex adaptive response. In human primary endothelial cells, we have recently shown the sequential intervention of various stress proteins which are crucial to prevent apoptosis and maintain cell function. We here demonstrate that mitophagy contributes to endothelial adaptation to gravitational unloading. After 4 and 10 d of exposure to simulated microgravity in the rotating wall vessel, the amount of BCL2 interacting protein 3, a marker of mitophagy, is increased and, in parallel, mitochondrial content, oxygen consumption, and maximal respiratory capacity are reduced, suggesting the acquisition of a thrifty phenotype to meet the novel metabolic challenges generated by gravitational unloading. Moreover, we suggest that microgravity induced-disorganization of the actin cytoskeleton triggers mitophagy, thus creating a connection between cytoskeletal dynamics and mitochondrial content upon gravitational unloading.
- Subjects :
- 0301 basic medicine
Acclimatization
Apoptosis
Mitochondrion
Biochemistry
Cell Line
03 medical and health sciences
0302 clinical medicine
Oxygen Consumption
Mitophagy
Genetics
Human Umbilical Vein Endothelial Cells
Humans
Cytoskeleton
Molecular Biology
Heat-Shock Proteins
Weightlessness Simulation
Thrifty phenotype
Chemistry
Weightlessness
Endothelial Cells
Actin cytoskeleton
Adaptation, Physiological
Actins
Cell biology
Mitochondria
030104 developmental biology
Phenotype
Simulated microgravity
Adaptation
030217 neurology & neurosurgery
Biotechnology
Subjects
Details
- ISSN :
- 15306860
- Volume :
- 34
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES
- Accession number :
- edsair.doi.dedup.....cbae0f8927f9584b50fdc67728cd2140