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Enterovirus-related diarrhoea in Guangdong, China: clinical features and implications in hand, foot and mouth disease and herpangina
- Source :
- BMC Infectious Diseases
- Publisher :
- Springer Nature
-
Abstract
- Background A series of complications caused by enteroviruses, including meningitis, encephalitis, acute flaccid paralysis, acute cardiopulmonary failure, respiratory infection, and myocardial injury have been reported in hand, foot and mouth disease/herpangina (HFMD/HA). However, the complication of diarrhoea caused by enteroviruses has been neglected, and a summary of its clinical features and impact on HFMD/HA is unavailable. Methods We included inpatients with HFMD/HA admitted to the Paediatric Department of Zhujiang Hospital during 2009–2012. We summarised and compared clinical data for cases with and without diarrhoea, and determined enterovirus serotypes by reverse transcriptase polymerase chain reaction and genotyping based on a partial-length fragment of viral protein 1 or the 5’-untranslated region. Results There were 804 inpatients with HFMD/HA and 28 (3.5 %) presented with diarrhoea. Gastrointestinal symptoms were mild in most cases of diarrhoea (82.1 %), with high prevalence of no dehydration (82.1 %), short duration of diarrhoea (78.6 %) and watery stools (75.0 %). The prevalence of multi-organ dysfunction syndrome (10.7 vs 0.40 %) (p = 0.001), hepatic injury (14.3 vs 3.4 %) (p = 0.019), myocardial injury (21.4 vs 6.1 %) (p = 0.002) and convulsion (21.4 vs 7.2 %) (p = 0.016) was significantly higher in the diarrhoea than no diarrhoea group. There was no significant difference between the two groups regarding prevalence of death, altered consciousness, paralysis, central nervous system involvement, or acute respiratory infection. Conclusions Most patients with diarrhoea caused by enteroviruses circulating in Guangdong Province in 2009–2012 had mild or moderate gastrointestinal symptoms. Although enterovirus-related diarrhoea caused additional multi-organ dysfunction syndrome, hepatic injury and myocardial injury in children with HFMD/HA, timely intervention efficiently reduced disease severity and improved outcome.
- Subjects :
- 0301 basic medicine
Diarrhea
Male
Pediatrics
medicine.medical_specialty
Herpangina
China
Adolescent
Genotype
030106 microbiology
medicine.disease_cause
03 medical and health sciences
stomatognathic system
medicine
Enterovirus Infections
Prevalence
Humans
Child
Enterovirus
Foot-and-mouth disease
business.industry
Respiratory infection
Clinical features
medicine.disease
Hand
Virology
Diarrhoea
Foot and mouth disease
030104 developmental biology
Infectious Diseases
Child, Preschool
Female
medicine.symptom
business
Complication
Hand, Foot and Mouth Disease
Meningitis
Encephalitis
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 14712334
- Volume :
- 16
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Infectious Diseases
- Accession number :
- edsair.doi.dedup.....cba5ba8266f250263be3fe02d404d5cf
- Full Text :
- https://doi.org/10.1186/s12879-016-1463-9