Back to Search
Start Over
Immuno-Imaging to Predict Treatment Response in Infection, Inflammation and Oncology
- Source :
- Journal of Clinical Medicine, Journal of Clinical Medicine, Vol 8, Iss 5, p 681 (2019)
- Publication Year :
- 2019
-
Abstract
- Background: Molecular nuclear medicine plays a pivotal role for diagnosis in a preclinical phase, in genetically susceptible patients, for radio-guided surgery, for disease relapse evaluation, and for therapy decision-making and follow-up. This is possible thanks to the development of new radiopharmaceuticals to target specific biomarkers of infection, inflammation and tumour immunology. Methods: In this review, we describe the use of specific radiopharmaceuticals for infectious and inflammatory diseases with the aim of fast and accurate diagnosis and treatment follow-up. Furthermore, we focus on specific oncological indications with an emphasis on tumour immunology and visualizing the tumour environment. Results: Molecular nuclear medicine imaging techniques get a foothold in the diagnosis of a variety of infectious and inflammatory diseases, such as bacterial and fungal infections, rheumatoid arthritis, and large vessel vasculitis, but also for treatment response in cancer immunotherapy. Conclusion: Several specific radiopharmaceuticals can be used to improve diagnosis and staging, but also for therapy decision-making and follow-up in infectious, inflammatory and oncological diseases where immune cells are involved. The identification of these cell subpopulations by nuclear medicine techniques would provide personalized medicine for these patients, avoiding side effects and improving therapeutic approaches.
- Subjects :
- Oncology
IN-VIVO DETECTION
medicine.medical_specialty
medicine.medical_treatment
TC-99M-INTERLEUKIN-2 SCINTIGRAPHY
lcsh:Medicine
Inflammation
Review
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Immune system
POSITRON-EMISSION-TOMOGRAPHY
Cancer immunotherapy
GIANT-CELL ARTERITIS
Internal medicine
PD-1 CHECKPOINT EXPRESSION
medicine
TUMOR-INFILTRATING LYMPHOCYTES
INTRAARTICULAR INFLIXIMAB
therapy follow-up
TC-99M-HMPAO-LABELED LEUKOCYTES
medicine.diagnostic_test
Tumor-infiltrating lymphocytes
business.industry
tumour immunology
lcsh:R
personalised medicine
General Medicine
medicine.disease
infection
RHEUMATOID-ARTHRITIS
Giant cell arteritis
Positron emission tomography
inflammation
030220 oncology & carcinogenesis
Rheumatoid arthritis
LARGE-VESSEL VASCULITIS
tumour microenvironment
Personalized medicine
medicine.symptom
business
Subjects
Details
- ISSN :
- 20770383
- Volume :
- 8
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of clinical medicine
- Accession number :
- edsair.doi.dedup.....cb92a63c8d6b308af746a62374a25c4a