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PLLA-collagen and PLLA-gelatin hybrid scaffolds with funnel-like porous structure for skin tissue engineering
- Source :
- Science and Technology of Advanced Materials, Vol 13, Iss 6, p 064210 (2012)
- Publication Year :
- 2012
-
Abstract
- In skin tissue engineering, a three-dimensional porous scaffold is necessary to support cell adhesion and proliferation and to guide cells moving into the repair area in the wound healing process. Structurally, the porous scaffold should have an open and interconnected porous architecture to facilitate homogenous cell distribution. Moreover, the scaffolds should be mechanically strong to protect deformation during the formation of new skin. In this study, the hybrid scaffolds were prepared by forming funnel-like collagen or gelatin sponge on a woven poly(l-lactic acid) (PLLA) mesh. The hybrid scaffolds combined the advantages of both collagen or gelatin (good cell-interactions) and PLLA mesh (high mechanical strength). The hybrid scaffolds were used to culture dermal fibroblasts for dermal tissue engineering. The funnel-like porous structure promoted homogeneous cell distribution and extracellular matrix production. The PLLA mesh reinforced the scaffold to avoid deformation. Subcutaneous implantation showed that the PLLA–collagen and PLLA–gelatin scaffolds promoted the regeneration of dermal tissue and epidermis and reduced contraction during the formation of new tissue. These results indicate that funnel-like hybrid scaffolds can be used for skin tissue regeneration.
- Subjects :
- Scaffold
Materials science
food.ingredient
Focus Papers
integumentary system
lcsh:Biotechnology
0206 medical engineering
02 engineering and technology
021001 nanoscience & nanotechnology
020601 biomedical engineering
Gelatin
Extracellular matrix
food
Homogeneous
Skin tissue
lcsh:TP248.13-248.65
lcsh:TA401-492
General Materials Science
lcsh:Materials of engineering and construction. Mechanics of materials
Composite material
0210 nano-technology
Cell adhesion
Porosity
Wound healing
Biomedical engineering
Subjects
Details
- ISSN :
- 14686996
- Volume :
- 13
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Science and technology of advanced materials
- Accession number :
- edsair.doi.dedup.....cb890c283d03b5e628a917156fbb940d