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Evaluation of Therapeutic Drug Monitoring of Methotrexate in Saliva of Children with Rheumatic Diseases
- Source :
- Therapeutic Drug Monitoring. 17:247
- Publication Year :
- 1995
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1995.
-
Abstract
- Pediatric patients with leukemia, other malignancies, and rheumatological disease receive methotrexate chronically. Because of the documented correlation between methotrexate levels of compliance and clinical outcome, it is conceivable to verify appropriate systemic exposure to the drug. Saliva sampling may be of potential interest, especially in children, in whom blood sampling is ethically limited. Our study shows poor correlation between serum total/free methotrexate concentrations and saliva levels, precluding the clinical use of this test.
- Subjects :
- Drug
medicine.medical_specialty
Systemic disease
Saliva
Adolescent
media_common.quotation_subject
Disease
Pharmacokinetics
Rheumatic Diseases
Internal medicine
medicine
Humans
Pharmacology (medical)
Child
media_common
Pharmacology
medicine.diagnostic_test
business.industry
medicine.disease
Methotrexate
Therapeutic drug monitoring
Child, Preschool
Immunology
Drug Monitoring
business
medicine.drug
Blood sampling
Subjects
Details
- ISSN :
- 01634356
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Therapeutic Drug Monitoring
- Accession number :
- edsair.doi.dedup.....cb8610091802beff140d15cefc43d42c
- Full Text :
- https://doi.org/10.1097/00007691-199506000-00006