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miR‑146a regulates the function of Th17 cell differentiation to modulate cervical cancer cell growth and apoptosis through NF‑κB signaling by targeting TRAF6
- Source :
- Oncology Reports.
- Publication Year :
- 2019
- Publisher :
- Spandidos Publications, 2019.
-
Abstract
- The aim of the present study was to investigate whether miRNA‑146a regulated the function of Th17 cell differentiation to modulate cervical cancer cell growth and apoptosis. miR‑146a expression was increased in human cervical cancer. Both overall survival (OS) and disease‑free survival (DFS) of low miR‑146a expression were higher than those of high miR‑146a expression. Additionally, IL‑17a expression was lower in patients with high miR‑146a expression compared to that of patients with lower miR‑146a expression. In a co‑culture of cervical cancer and CD4+ T cells, downregulation of miR‑146a inhibited cell growth and induced apoptosis of cervical cancer cells, while overexpression of miR‑146a promoted cell growth and reduced apoptosis of cervical cancer cells. Downregulation of miR‑146a induced TRAF6 and NF‑κB protein expression, increased IL‑6, IL‑17A and IL‑21 levels, and enhanced p‑STAT3 protein expression. The inhibition of TRAF6 attenuated the effects of anti‑miR‑146a on the function of Th17 cell differentiation to modulate cervical cancer cell growth and apoptosis. Collectively, miR‑146a regulated the function of Th17 cell differentiation to modulate cervical cancer cell growth and apoptosis through NF‑κB signaling by targeting TRAF6. miR‑146a may function as an oncogene in cervical cancer via Th17 cell differentiation by targeting TRAF6.
- Subjects :
- 0301 basic medicine
Cancer Research
Cellular differentiation
Cell
Uterine Cervical Neoplasms
Apoptosis
Biology
Disease-Free Survival
03 medical and health sciences
0302 clinical medicine
Downregulation and upregulation
Cell Line, Tumor
medicine
Humans
Aged
Cell Proliferation
TNF Receptor-Associated Factor 6
Oncogene
Cell growth
Intracellular Signaling Peptides and Proteins
NF-kappa B
Cancer
Cell Differentiation
General Medicine
Middle Aged
Cell cycle
medicine.disease
Gene Expression Regulation, Neoplastic
MicroRNAs
030104 developmental biology
medicine.anatomical_structure
Oncology
Case-Control Studies
030220 oncology & carcinogenesis
Cancer research
Th17 Cells
Female
Signal Transduction
Subjects
Details
- ISSN :
- 17912431 and 1021335X
- Database :
- OpenAIRE
- Journal :
- Oncology Reports
- Accession number :
- edsair.doi.dedup.....cb7aa8444ede38eee6bf70bfb8203ea8