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Aggressive versus conventional strategies in the treatment of rectal adenocarcinoma
- Source :
- Surgical Oncology. 5:183-188
- Publication Year :
- 1996
- Publisher :
- Elsevier BV, 1996.
-
Abstract
- Objective: Comparison of an aggressive approach (including total mesorectal excision and combined modality adjuvant therapy) with a conventional approach in the treatment of primary rectal cancer. Design: Retrospective study. Setting: Memorial Sloan-Kettering Cancer Centre, New York (MSKCC) and University Hospital Leiden, the Netherlands (UHL). Subjects: One hundred and sixty-nine patients treated at MSKCC and 96 patients treated at UHL. Interventions: Total mesorectal excision (MSKCC) and conventional resection (UHL). Main outcome measures: Overall survival and local recurrence-free survival. Results: Five-year overall survival was 73% for MSKCC patients and 52% for UHL patients [ P P = 0.001). Relative risk of dying or developing a local recurrence was 3.37 and 2.61, respectively, for patients treated at UHL compared to patients treated at MSKCC ( P P = 0.008, respectively). Conclusions: These data suggest that an aggressive approach including total mesorectal excision and combined modality adjuvant therapy improves survival and local control compared to a conventional approach.
- Subjects :
- Male
Oncology
medicine.medical_specialty
Colorectal cancer
medicine.medical_treatment
Adenocarcinoma
Disease-Free Survival
Internal medicine
Adjuvant therapy
Rectal Adenocarcinoma
Humans
Medicine
Combined Modality Therapy
Survival rate
Aged
Retrospective Studies
Aged, 80 and over
Rectal Neoplasms
business.industry
Retrospective cohort study
Middle Aged
medicine.disease
Total mesorectal excision
Surgery
Survival Rate
Radiation therapy
Chemotherapy, Adjuvant
Female
Radiotherapy, Adjuvant
Neoplasm Recurrence, Local
business
Subjects
Details
- ISSN :
- 09607404
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Surgical Oncology
- Accession number :
- edsair.doi.dedup.....cb7a81f0ad9fac96bdbfb6a02aaa104b