Back to Search
Start Over
Effect of Dapagliflozin as an Add-on Therapy to Insulin on the Glycemic Variability in Subjects with Type 2 Diabetes Mellitus (DIVE): A Multicenter, Placebo-Controlled, Double-Blind, Randomized Study
- Source :
- Diabetes & Metabolism Journal, Diabetes & Metabolism Journal, Vol 45, Iss 3, Pp 339-348 (2021)
- Publication Year :
- 2021
- Publisher :
- Korean Diabetes Association, 2021.
-
Abstract
- Background Glycemic variability is associated with the development of diabetic complications and hypoglycemia. However, the effect of sodium-glucose transporter 2 (SGLT2) inhibitors on glycemic variability is controversial. We aimed to examine the effect of dapagliflozin as an add-on therapy to insulin on the glycemic variability assessed using continuous glucose monitoring (CGM) in subjects with type 2 diabetes mellitus. Methods In this multicenter, placebo-controlled, double-blind, randomized study, 84 subjects received 10 mg of dapagliflozin (n=41) or the placebo (n=43) for 12 weeks. CGM was performed before and after treatment to compare the changes in glycemic variability measures (standard deviation [SD], mean amplitude of glycemic excursions [MAGEs]). Results At week 12, significant reductions in glycosylated hemoglobin (−0.74%±0.66% vs. 0.01%±0.65%, P
- Subjects :
- Blood Glucose
medicine.medical_specialty
Drug/Regimen
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
030209 endocrinology & metabolism
030204 cardiovascular system & hematology
Hypoglycemia
Placebo
Gastroenterology
Diseases of the endocrine glands. Clinical endocrinology
law.invention
03 medical and health sciences
chemistry.chemical_compound
Diabetes mellitus
0302 clinical medicine
Glucosides
Randomized controlled trial
law
Sodium-glucose transporter 2 inhibitors
Internal medicine
medicine
Humans
Hypoglycemic Agents
Insulin
Benzhydryl Compounds
Dapagliflozin
Glycemic
business.industry
Blood Glucose Self-Monitoring
Type 2 Diabetes Mellitus
RC648-665
medicine.disease
Diabetes Mellitus, Type 2
chemistry
Original Article
business
Subjects
Details
- ISSN :
- 22336087 and 22336079
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Diabetes & Metabolism Journal
- Accession number :
- edsair.doi.dedup.....cb724707a99dd5f700f8acc0920a7524