Expression of NG2 proteoglycan in the degenerated intervertebral disc in dachshunds

Authors :: Mohammed A.H. Abdelhakiem
Ayuko Yamashita
Masaaki Katayama
Hiroshi Isomura
Ayman Atiba
Yuji Uzuka
H.A. Youssef
Yasuhiko Okamura
Source :: The Journal of Veterinary Medical Science
Publication Year :: 2015
Publisher :: The Japanese Society of Veterinary Science, 2015.
Abstract: The pathogenesis of intervertebral disc (IVD) degeneration is not fully understood. The biomolecular signaling pathways involved in the IVD degeneration require further investigation. The aim of this study was to investigate the expression of NG2 proteoglycan in the degenerated IVD. IVD samples were obtained from 16 Dachshunds that were confirmed to have IVD herniation and subsequently underwent hemilaminectomy. The samples were subjected to histological and immunohistochemical (IHC) examinations. IHC revealed positive results for the expression of NG2 proteoglycan in all examined samples. The results showed the expression of NG2 proteoglycan by the degenerated IVDs.

Tools