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Serotonin mediated immunoregulation and neural functions: Complicity in the aetiology of autism spectrum disorders
- Source :
- Neuroscience and biobehavioral reviews. 55
- Publication Year :
- 2015
-
Abstract
- Serotonergic system has long been implicated in the aetiology of autism spectrum disorders (ASD), since platelet hyperserotonemia is consistently observed in a subset of autistic patients, who respond well to selective serotonin reuptake inhibitors. Apart from being a neurotransmitter, serotonin functions as a neurotrophic factor directing brain development and as an immunoregulator modulating immune responses. Serotonin transporter (SERT) regulates serotonin level in lymphoid tissues to ensure its proper functioning in innate and adaptive responses. Immunological molecules such as cytokines in turn regulate the transcription and activity of SERT. Dysregulation of serotonergic system could trigger signalling cascades that affect normal neural-immune interactions culminating in neurodevelopmental and neural connectivity defects precipitating behavioural abnormalities, or the disease phenotypes. Therefore, we suggest that a better understanding of the cross talk between serotonergic genes, immune systems and serotonergic neurotransmission will open wider avenues to develop pharmacological leads for addressing the core ASD behavioural deficits.
- Subjects :
- Serotonin
Autism Spectrum Disorder
Cognitive Neuroscience
Autoimmunity
Serotonergic
Autoimmune Diseases
Behavioral Neuroscience
chemistry.chemical_compound
Neurotrophic factors
medicine
Animals
Humans
Neurotransmitter
Serotonin transporter
Neuroinflammation
Serotonin Plasma Membrane Transport Proteins
Innate immune system
biology
Brain
medicine.disease
Neuropsychology and Physiological Psychology
chemistry
Immune System
biology.protein
Autism
Encephalitis
Neuroscience
Subjects
Details
- ISSN :
- 18737528
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Neuroscience and biobehavioral reviews
- Accession number :
- edsair.doi.dedup.....cb609e82ba5bf242b35568b0553b93db