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Mixed adenoneuroendocrine carcinoma with loss of HER2 positivity after trastuzumab-based chemotherapy for HER2-positive gastric cancer: a case report
- Source :
- Surgical Case Reports, Surgical Case Reports, Vol 6, Iss 1, Pp 1-6 (2020)
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Background Trastuzumab (T-mab)-based chemotherapy is a standard regimen for human epithelial growth factor 2 (HER2)-positive gastric cancer. However, some patients have demonstrated a change in HER2 status after T-mab-based treatment of breast cancer. We report a rare case of mixed adenoneuroendocrine carcinoma with loss of HER2 positivity after T-mab-based chemotherapy for HER2-positive gastric cancer. Case presentation A 60-year-old man presented with a mass of the upper abdomen, which was diagnosed as adenocarcinoma with a HER2 score of 3+ by endoscopic biopsy. He received seven cycles of combination chemotherapy with capecitabine, cisplatin, and T-mab. Subsequently, he underwent open total gastrectomy, distal pancreatosplenectomy, and extended left hepatic lobectomy as a conversion surgery. The surgically resected specimen demonstrated both adenocarcinoma and neuroendocrine components; therefore, it was diagnosed as HER2-negative mixed adenoneuroendocrine carcinoma. Although the patient received additional chemotherapy, multiple liver metastases appeared at 3 months postoperatively and he died at 6 months postoperatively because of the rapidly progressing metastatic tumor. Conclusions We encountered a rare case of rapidly progressive mixed adenoneuroendocrine carcinoma that was negative for HER2 expression after T-mab treatment combined with chemotherapy.
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
lcsh:Surgery
Case Report
Gastroenterology
Conversion surgery
Capecitabine
03 medical and health sciences
Trastuzumab-based chemotherapy
0302 clinical medicine
Breast cancer
Internal medicine
medicine
skin and connective tissue diseases
Liver metastasis
Chemotherapy
business.industry
Cancer
Combination chemotherapy
lcsh:RD1-811
Prognosis
medicine.disease
Regimen
030220 oncology & carcinogenesis
Adenocarcinoma
030211 gastroenterology & hepatology
Gastrectomy
Gastric cancer
business
medicine.drug
Subjects
Details
- ISSN :
- 21987793
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Surgical Case Reports
- Accession number :
- edsair.doi.dedup.....cb5c757d2dde1e80044b7f2db9cec9a7