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Attenuation correction for small animal PET tomographs
- Source :
- Chow, Patrick L; Rannou, Fernando R; & Chatziioannou, Arion F. (2005). Attenuation correction for small animal PET tomographs. Physics in Medicine and Biology, 50(8), 1837-1850. UCLA: Retrieved from: http://www.escholarship.org/uc/item/41n377p3
- Publication Year :
- 2005
-
Abstract
- Attenuation correction is one of the important corrections required for quantitative positron emission tomography (PET). This work will compare the quantitative accuracy of attenuation correction using a simple global scale factor with traditional transmission-based methods acquired either with a small animal PET or a small animal x-ray computed tomography (CT) scanner. Two phantoms (one mouse-sized and one rat-sized) and two animal subjects (one mouse and one rat) were scanned in CTI Concorde Microsystem's MicroPET(R) Focus(TM) for emission and transmission data and in ImTek's MicroCAT(TM) II for transmission data. PET emission image values were calibrated against a scintillation well counter. Results indicate that the scale factor method of attenuation correction places the average measured activity concentration about the expected value, without correcting for the cupping artefact from attenuation. Noise analysis in the phantom studies with the PET-based method shows that noise in the transmission data increases the noise in the corrected emission data. The CT-based method was accurate and delivered low-noise images suitable for both PET data correction and PET tracer localization.
- Subjects :
- Scanner
Sensitivity and Specificity
Article
law.invention
Rats, Sprague-Dawley
Mice
Optics
law
Image Interpretation, Computer-Assisted
medicine
Animals
Scattering, Radiation
Radiology, Nuclear Medicine and imaging
Physics
Scintillation
Mice, Inbred C3H
microCT
Radiological and Ultrasound Technology
medicine.diagnostic_test
business.industry
Noise (signal processing)
Phantoms, Imaging
Attenuation
Reproducibility of Results
Well counter
attenuation correction
Scale factor
Image Enhancement
microPET
Rats
Positron emission tomography
Positron-Emission Tomography
Subtraction Technique
Nuclear medicine
business
Artifacts
Tomography, X-Ray Computed
Correction for attenuation
Algorithms
Subjects
Details
- ISSN :
- 00319155
- Volume :
- 50
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Physics in medicine and biology
- Accession number :
- edsair.doi.dedup.....cb5b7ffd8eb7db775c5523df051b69b0