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Treatment Options in the Modern Management of Parkinson Disease
- Source :
- Archives of Neurology. 64:1083
- Publication Year :
- 2007
- Publisher :
- American Medical Association (AMA), 2007.
-
Abstract
- Dopamine replacement therapy with levodopa has been the mainstay of symptomatic treatment of Parkinson disease (PD) for almost 40 years. While this drug remains the "gold standard," several additional dopaminergic drugs have been introduced to provide alternatives for patients with PD. Practical challenges in the management of PD include determining the point at which drug therapy should begin and with what, the sequence and combination of drugs required as the disease progresses, and the place for parenteral therapy and surgery in advanced disease. Although levodopa offers effective symptom relief at all stages, its risk of inducing motor complications has led many to advocate alternative drugs for initiation in suitable patients. Dopamine agonists and monoamine oxidase (MAO) B inhibitors offer effective relief of the motor features of PD in early and more advanced disease and are associated with a low risk for motor complications. However, they are not as potent as levodopa. Parenteral dopamine agonist or levodopa delivery offers a useful intermediate or alternative to surgery.
- Subjects :
- Drug
medicine.medical_specialty
Levodopa
media_common.quotation_subject
Dopamine Agents
Disease
Dopamine agonist
law.invention
Pharmacotherapy
Arts and Humanities (miscellaneous)
Randomized controlled trial
law
Dopamine
medicine
Humans
Intensive care medicine
media_common
Movement Disorders
business.industry
Dopaminergic
Neurodegenerative Diseases
Parkinson Disease
Surgery
Neurology
Disease Progression
Drug Therapy, Combination
Neurology (clinical)
business
medicine.drug
Subjects
Details
- ISSN :
- 00039942
- Volume :
- 64
- Database :
- OpenAIRE
- Journal :
- Archives of Neurology
- Accession number :
- edsair.doi.dedup.....cb5ad4fb5271b72b93d4913d1cae324b