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Classification of Huntington’s Disease Stage with Features Derived from Structural and Diffusion-Weighted Imaging
- Source :
- Journal of Personalized Medicine; Volume 12; Issue 5; Pages: 704
- Publication Year :
- 2022
- Publisher :
- MDPI AG, 2022.
-
Abstract
- The purpose of this study was to classify Huntington’s disease (HD) stage using support vector machines and measures derived from T1- and diffusion-weighted imaging. The effects of feature selection approach and combination of imaging modalities are assessed. Fourteen premanifest-HD individuals (Pre-HD; on average > 20 years from estimated disease onset), eleven early-manifest HD (Early-HD) patients, and eighteen healthy controls (HC) participated in the study. We compared three feature selection approaches: (i) whole-brain segmented grey matter (GM; voxel-based measure) or fractional anisotropy (FA) values; (ii) GM or FA values from subcortical regions-of-interest (caudate, putamen, pallidum); and (iii) automated selection of GM or FA values with the algorithm Relief-F. We assessed single- and multi-kernel approaches to classify combined GM and FA measures. Significant classifications were achieved between Early-HD and Pre-HD or HC individuals (accuracy: generally, 85% to 95%), and between Pre-HD and controls for the feature FA of the caudate ROI (74% accuracy). The combination of GM and FA measures did not result in higher performances. We demonstrate evidence on the high sensitivity of FA for the classification of the earliest Pre-HD stages, and successful distinction between HD stages.
Details
- ISSN :
- 20754426
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Journal of Personalized Medicine
- Accession number :
- edsair.doi.dedup.....cb551de7205ec6eb3203d0e09216fa6e