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TTX-resistant NMDA receptor-mediated voltage oscillations in mammalian lumbar motoneurons
- Source :
- Journal of Neurophysiology. 72:2559-2562
- Publication Year :
- 1994
- Publisher :
- American Physiological Society, 1994.
-
Abstract
- 1. Whole cell current-clamp recordings were obtained from tetrodotoxin (TTX)-isolated motoneurons in the in vitro neonatal rat spinal cord to examine the effects of N-methyl-D-aspartate (NMDA) receptor activation on membrane voltage. 2. NMDA induced rhythmic membrane voltage oscillations, and injection of current ramps revealed the presence of bistable membrane properties, the base and peak of which corresponded to the base and peak values of the voltage oscillations. 3. Nonlinear motoneuron membrane properties induced by NMDA receptor activation may be well suited to reinforce rhythmic patterns of motor output during certain behaviors such as locomotion.
- Subjects :
- Physiology
Tetrodotoxin
Receptors, N-Methyl-D-Aspartate
Synaptic Transmission
Membrane Potentials
Rats, Sprague-Dawley
chemistry.chemical_compound
Lumbar
medicine
Animals
Receptor
Cells, Cultured
Motor Neurons
Neonatal rat
General Neuroscience
Spinal cord
Electric Stimulation
In vitro
Rats
Cell biology
medicine.anatomical_structure
Animals, Newborn
Spinal Cord
nervous system
chemistry
NMDA receptor
Whole cell
Locomotion
Subjects
Details
- ISSN :
- 15221598 and 00223077
- Volume :
- 72
- Database :
- OpenAIRE
- Journal :
- Journal of Neurophysiology
- Accession number :
- edsair.doi.dedup.....cb4c3c29937a70fbdcbfb7dd1c5a28ad