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Ultradeformable liposomes as multidrug carrier of resveratrol and 5-fluorouracil for their topical delivery

Authors :
Cinzia Anna Ventura
Donato Cosco
Donatella Paolino
Luisa Di Marzio
Maria Carafa
Massimo Fresta
Jessica Maiuolo
Source :
International Journal of Pharmaceutics. 489:1-10
Publication Year :
2015
Publisher :
Elsevier BV, 2015.

Abstract

Ultradeformable liposomes represent useful formulations able to increase the skin permeation of drug compounds. In this study, resveratrol- and 5-fluorouracil-loaded ultradeformable liposomes were investigated for the potential treatment of non-melanoma skin cancer. The in vitro anticancer activity of ultradeformable liposomes was tested on human skin cancer cells through viability-, cell cycle- and apoptosis-analysis. Furthermore, we tested the percutaneous permeation of ultradeformable liposomes using human stratum corneum and viable epidermis. The co-encapsulation of resveratrol and 5-fluorouracil (multi-drug carrier) in ultradeformable liposomes improved their anticancer activity on skin cancer cells as compared to both the free drug form and the single entrapped agents. These multi-drug ultradeformable liposomes arrest cell proliferation in G1/S, thus modifying the action of 5-fluorouracil and increasing the activity of resveratrol. This effect might depend on the ultradeformable liposomes, which may accumulate in deeper skin layers, thus generating a cutaneous depot from which resveratrol and 5-fluorouracil are gradually released. Resveratrol and 5-fluorouracil co-loaded ultradeformable liposomes could be a new nanomedicine for the treatment of squamous cell carcinoma, i.e., actinic keratosis, Bowen's disease, and keratoacanthoma.

Details

ISSN :
03785173
Volume :
489
Database :
OpenAIRE
Journal :
International Journal of Pharmaceutics
Accession number :
edsair.doi.dedup.....cb4b34b1d534d19a7f64edfe3e14d915
Full Text :
https://doi.org/10.1016/j.ijpharm.2015.04.056