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Ultradeformable liposomes as multidrug carrier of resveratrol and 5-fluorouracil for their topical delivery
- Source :
- International Journal of Pharmaceutics. 489:1-10
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Ultradeformable liposomes represent useful formulations able to increase the skin permeation of drug compounds. In this study, resveratrol- and 5-fluorouracil-loaded ultradeformable liposomes were investigated for the potential treatment of non-melanoma skin cancer. The in vitro anticancer activity of ultradeformable liposomes was tested on human skin cancer cells through viability-, cell cycle- and apoptosis-analysis. Furthermore, we tested the percutaneous permeation of ultradeformable liposomes using human stratum corneum and viable epidermis. The co-encapsulation of resveratrol and 5-fluorouracil (multi-drug carrier) in ultradeformable liposomes improved their anticancer activity on skin cancer cells as compared to both the free drug form and the single entrapped agents. These multi-drug ultradeformable liposomes arrest cell proliferation in G1/S, thus modifying the action of 5-fluorouracil and increasing the activity of resveratrol. This effect might depend on the ultradeformable liposomes, which may accumulate in deeper skin layers, thus generating a cutaneous depot from which resveratrol and 5-fluorouracil are gradually released. Resveratrol and 5-fluorouracil co-loaded ultradeformable liposomes could be a new nanomedicine for the treatment of squamous cell carcinoma, i.e., actinic keratosis, Bowen's disease, and keratoacanthoma.
- Subjects :
- Drug
Skin Neoplasms
Cell Survival
Skin Absorption
media_common.quotation_subject
Pharmaceutical Science
Antineoplastic Agents
Apoptosis
Human skin
In Vitro Techniques
Resveratrol
Pharmacology
Administration, Cutaneous
chemistry.chemical_compound
Cell Line, Tumor
Stilbenes
Skin delivery
Multi-drug colloidal carriers, Skin cancer, Skin delivery, Supramolecular therapeutics, Ultradeformable liposomes
medicine
Stratum corneum
Humans
multi-drug colloidal carriers
Ultradeformable liposomes
Skin
media_common
skin cancer
supramolecular therapeutics
integumentary system
Cell growth
Cell Cycle
Actinic keratosis
medicine.disease
medicine.anatomical_structure
chemistry
Liposomes
Cancer cell
Fluorouracil
Skin cancer
Subjects
Details
- ISSN :
- 03785173
- Volume :
- 489
- Database :
- OpenAIRE
- Journal :
- International Journal of Pharmaceutics
- Accession number :
- edsair.doi.dedup.....cb4b34b1d534d19a7f64edfe3e14d915
- Full Text :
- https://doi.org/10.1016/j.ijpharm.2015.04.056