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Interleukin-33 exacerbates acute colitis via interleukin-4 in mice
- Source :
- Immunology, Immunology, Wiley, 2013, 140 (1), pp.70-77. ⟨10.1111/imm.12111⟩
- Publication Year :
- 2013
-
Abstract
- Pushparaj, Peter N Li, Dong Komai-Koma, Mousa Guabiraba, Rodrigo Alexander, James McSharry, Charles Xu, Damo Arthritis Research UK/United Kingdom Medical Research Council/United Kingdom Wellcome Trust/United Kingdom England Immunology. 2013 Sep;140(1):70-7. doi: 10.1111/imm.12111.; International audience; Interleukin-33 (IL-33) and its receptor ST2 are over-expressed in clinical colitis tissue. However, the significance of these observations is at present unknown. Significantly, we demonstrate here that IL33 and ST2 are the primary early genes induced in the inflamed colon of BALB/c mice following dextran sulphate sodium (DSS)-induced experimental ulcerative colitis. Accordingly diarrhoea and DSS-induced colon inflammation were impaired in ST2(-/-) BALB/c mice and exacerbated in wild-type mice by treatment with exogenous recombinant IL-33, associated respectively with reduced and enhanced expression of chemokines (CXCL9 and CXCL10), and inflammatory (IL-4, IL-13, IL-1, IL-6, IL-17) and angiogenic (vascular endothelial growth factor) cytokines in vivo. The exacerbation effect of treatment with recombinant IL-33 on DSS-induced acute colitis was abolished in IL-4(-/-) BALB/c mice. Hence, IL-33 signalling via ST2, by inducing an IL-4-dependent immune response, may be a major pathogenic factor in the exacerbation of ulcerative colitis.
- Subjects :
- Chemokine
Exacerbation
colitis
Immunology
Gene Expression
03 medical and health sciences
Mice
0302 clinical medicine
Immunology and Allergy
Medicine
Animals
Colitis
interleukin-4 deficiency
Interleukin 4
Acute colitis
030304 developmental biology
ST2 deficiency
Mice, Knockout
0303 health sciences
Mice, Inbred BALB C
biology
business.industry
Interleukins
Receptors, Interleukin
Original Articles
medicine.disease
Interleukin-33
Ulcerative colitis
Interleukin-1 Receptor-Like 1 Protein
early interleukin-33 expression
3. Good health
Receptors, Interleukin-4
Interleukin 33
030220 oncology & carcinogenesis
Acute Disease
biology.protein
CXCL9
[SDV.IMM]Life Sciences [q-bio]/Immunology
Cytokines
Colitis, Ulcerative
Female
Interleukin-4
Chemokines
Inflammation Mediators
business
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Signal Transduction
Subjects
Details
- ISSN :
- 13652567 and 00192805
- Volume :
- 140
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Immunology
- Accession number :
- edsair.doi.dedup.....cb483f706e137c1590a559a13618a290