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Fulminant Hepatitis Induced by Lamotrigine
- Source :
- Southern Medical Journal. 102:82-84
- Publication Year :
- 2009
- Publisher :
- Southern Medical Association, 2009.
-
Abstract
- Anticonvulsant hypersensitivity syndrome (AHS) is a potentially life-threatening adverse drug reaction presenting with fever, skin eruptions, and internal organ involvement. We describe a case of AHS with fulminant hepatitis that occurred two weeks after introduction of lamotrigine in a 40-year-old female patient with a recently diagnosed bipolar disorder, no pre-existent systemic organ involvement, and no other medication. Lamotrigine was introduced at a dosage of 25 mg daily and increased to 50 mg daily 12 days later. The patient had favorable evolution with cessation of lamotrigine and supportive treatment. This report suggests that AHS with fulminant hepatitis may occur idiosyncratically, independent of dosage, titration and comedication with other potentially hepatotoxic drugs.
- Subjects :
- Adult
medicine.medical_specialty
Bipolar Disorder
Lamotrigine
Internal medicine
Female patient
medicine
Humans
Bipolar disorder
Fulminant hepatitis
Triazines
business.industry
Liver failure
General Medicine
Liver Failure, Acute
medicine.disease
Anticonvulsant hypersensitivity syndrome
Organ involvement
Anticonvulsants
Female
Neurotoxicity Syndromes
Chemical and Drug Induced Liver Injury
business
Adverse drug reaction
medicine.drug
Subjects
Details
- ISSN :
- 00384348
- Volume :
- 102
- Database :
- OpenAIRE
- Journal :
- Southern Medical Journal
- Accession number :
- edsair.doi.dedup.....cb3667785f713b9d46430f9c021903d9