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Diversity of human papillomavirus in the anal canal of HIV-positive and HIV-negative men
- Source :
- Journal of Infection. 82:112-116
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Summary Background To characterize the HPV diversity in the anal mucosa of men with different sexual behavior and HIV status by next-generation sequencing (NGS). Methods Anal swabs from HIV-positive (n = 94; mean age, 38 years) and HIV-negative (n = 100; mean age, 37.5 years) men who have sex with men (MSM) and HIV-negative men (predominantly men who have sex with women, MSW) (n = 99; mean age, 38.2 years) were analyzed by broad-spectrum PCR protocols combined with NGS. Findings Alpha HPV types (n = 74) were detected mainly in the MSM groups (HPV6, 11, and 43 were the most abundant types) compared with MSW (n = 16) (HPV11, 32, and 87 were among the most abundant). In contrast, beta HPVs were more abundantly detected among MSW (n = 45) than in the HIV-positive (n = 16) and HIV-negative (n = 26) MSM groups. Gamma HPVs were detected almost equally in HIV-positive MSM (n = 62), HIV-negative MSM (n = 58), and MSW (n = 57). In addition, 31 putative novel PV types were identified. Conclusions Our data show that beta and gamma HPV types are present in the anal mucosa, thus reinforcing the existing evidence that they can be detected at anatomical sites other than skin. Alpha and beta HPV distribution among these three groups appears to vary according to sexual behavior.
- Subjects :
- Adult
Male
0301 basic medicine
Microbiology (medical)
030106 microbiology
Human immunodeficiency virus (HIV)
Anal Canal
Physiology
HIV Infections
Alphapapillomavirus
medicine.disease_cause
Men who have sex with men
Sexual and Gender Minorities
03 medical and health sciences
0302 clinical medicine
Risk Factors
Prevalence
Humans
Medicine
030212 general & internal medicine
Homosexuality, Male
Human papillomavirus
Papillomaviridae
Hpv types
business.industry
Papillomavirus Infections
virus diseases
Anal canal
Infectious Diseases
Anatomical sites
medicine.anatomical_structure
Sexual behavior
Female
Hiv status
business
Subjects
Details
- ISSN :
- 01634453
- Volume :
- 82
- Database :
- OpenAIRE
- Journal :
- Journal of Infection
- Accession number :
- edsair.doi.dedup.....cb2e84faf7ca6b0df4351cc9706be049