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Autophagy Shapes Inflammation
- Source :
- Antioxidants & Redox Signaling. 14:2233-2243
- Publication Year :
- 2011
- Publisher :
- Mary Ann Liebert Inc, 2011.
-
Abstract
- Autophagy is a basic cell biological process ongoing under physiologic circumstances in almost all cell types of the human organism and upregulated by various stress conditions including those leading to inflammation. Since autophagy affects the effector cells of innate and adaptive immunity mediating the inflammatory response, its activity in these cells influences the antimicrobial response, the development of an effective cognate immune defense, and the course of the normal sterile inflammatory reactions. The level of autophagic activity may determine whether tissue cells die by apoptosis, necrosis, or through autophagy, and, as a consequence, whether the clearance of these dying cells is a silent process or results in an inflammatory response. Loss or decreased autophagy may lead to necrotic death that can initiate an inflammatory reaction in phagocytes through their surface and cytosolic receptors. Engulfment of certain cells dying through autophagy can activate the inflammasome. The intertwining regulatory connections between inflammation and immunity extend to pathologic conditions including chronic inflammatory diseases, autoimmunity and cancer.
- Subjects :
- Programmed cell death
Cell type
Necrosis
Physiology
Clinical Biochemistry
Apoptosis
Inflammation
Adaptive Immunity
Biology
Biochemistry
Crohn Disease
Neoplasms
Autophagy
medicine
Animals
Humans
Elméleti orvostudományok
Molecular Biology
General Environmental Science
Effector
Neurodegenerative Diseases
Inflammasome
Orvostudományok
Cell Biology
Acquired immune system
Immunity, Innate
Cell biology
Lysosomal Storage Diseases
General Earth and Planetary Sciences
medicine.symptom
medicine.drug
Subjects
Details
- ISSN :
- 15577716 and 15230864
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Antioxidants & Redox Signaling
- Accession number :
- edsair.doi.dedup.....cb28586ce15d6f39532a65432b67958f