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microRNA-21 expression is elevated in esophageal adenocarcinoma after neoadjuvant chemotherapy

Authors :
Matthias Preusser
Sebastian F. Schoppmann
Aysegül Ilhan-Mutlu
Georgios Karanikas
Kommata Spyridoula
Peter Birner
Gulcin Tezcan
Source :
Cancer investigation. 33(6)
Publication Year :
2015

Abstract

We investigated whether microRNA-21 and microRNA-148a are predictive for neoadjuvant treatment in esophageal adenocarcinoma. Thirty-six patients with neoadjuvant therapy and surgical resection were included. FFPE tissue from biopsy and esophagectomy were analyzed using RT-qPCR. Results were correlated to histological tumor regression, histopathological variables, FDG-PET–CT and survival. MicroRNA-21 was significantly higher in esophagectomies than in corresponding biopsies (p = .027). No association of microRNA-21 or microRNA-148a expression in tissue specimens with other clinical parameters was present. Although no influence of microRNA-21 and microRNA-148a on the response to neoadjuvant therapy was seen, upregulation of microRNA-21 might represent an escape mechanism of tumor cells.

Details

ISSN :
15324192
Volume :
33
Issue :
6
Database :
OpenAIRE
Journal :
Cancer investigation
Accession number :
edsair.doi.dedup.....cb2448699ea812d850c8ff22d6885875